NHC-Catalyzed Radical Tandem Cyclization/Coupling Reaction for the Synthesis of 2-Pyrrolidinone Derivatives

被引：3

作者：

Zhou, Nengneng ^{[1
]}

Wang, Lei ^{[1
]}

Zhao, Fangli ^{[1
]}

Gao, Xiang ^{[1
]}

Zhao, Xiaowei ^{[1
]}

Zhang, Man ^{[1
,2
]}

机构：

[1] Anhui Normal Univ, Coll Chem & Mat Sci, Key Lab Functionalized Mol Solids, Anhui Key Lab Mol Based Mat,Minist Educ, Wuhu 241000, Anhui, Peoples R China

[2] Anhui Normal Univ, Sch Phys & Elect Informat, Wuhu 241000, Anhui, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 12卷 / 09期

基金：

中国国家自然科学基金;

关键词：

metal-free; NHC-catalyzed; 2-pyrrolidinons; radical coupling; tandem radical cyclization; EFFICIENT SYNTHESIS; GAMMA-LACTAMS; CARBENE; AMINODIFLUOROALKYLATION; ALKENES;

D O I：

10.1002/ajoc.202300334

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel strategy for synthesizing structurally diverse 2-pyrrolidinons by a NHC-catalyzed tandem radical cyclization process has been developed. This reaction proceeds through a radical coupling approach, which not only shows broad substrate scope with excellent functional group compatibility but also is quite compatible with the secondary and tertiary radicals. By using this protocol, various potentially bioactive 2-pyrrolidinons were facilely synthesized.

引用

页数：5

共 43 条

[41] Synthesis of 2-pyrrolidinone derivatives via N-heterocyclic carbene catalyzed radical tandem cyclization/coupling reactions [J].