Radiation-induced circulating microRNAs linked to echocardiography parameters after radiotherapy

被引:2
作者
Chalubinska-Fendler, Justyna [1 ]
Nowicka, Zuzanna [2 ]
Drozdz, Izabela [3 ]
Graczyk, Lukasz [4 ,5 ]
Piotrowski, Grzegorz [6 ,7 ]
Tomasik, Bartlomiej [2 ,8 ]
Spych, Michal [9 ]
Fijuth, Jacek [5 ,9 ]
Papis-Ubych, Anna [5 ]
Kedzierawski, Piotr [10 ]
Kozono, David [11 ]
Fendler, Wojciech [2 ,11 ]
机构
[1] Mil Inst Med, Natl Res Inst, Dept Radiotherapy, Warsaw, Poland
[2] Med Univ Lodz, Dept Biostat & Translat Med, Lodz, Poland
[3] Med Univ Lodz, Dept Clin Genet, Lodz, Poland
[4] Oncol Ctr Radom, Dept Radiat Oncol, Radom, Poland
[5] Copernicus Mem Hosp Lodz, Reg Canc Ctr, Dept Teleradiotherapy, Lodz, Poland
[6] Med Univ Lodz, Cardiooncol Dept, Lodz, Poland
[7] Nicolaus Copernicus Mem Hosp, Cardiol Dept, Lodz, Poland
[8] Med Univ Gdansk, Fac Med, Dept Oncol & Radiotherapy, Gdansk, Poland
[9] Med Univ Lodz, Chair Oncol, Dept Radiotherapy, Lodz, Poland
[10] Holy Cross Canc Ctr, Dept Radiotherapy, Kielce, Poland
[11] Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02115 USA
来源
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
关键词
breast cancer; radiation-induced cardiac toxicity; echocardiography; biomarkers; microRNA; BREAST-CANCER; HEART; THERAPY; HYPERTROPHY; EXPRESSION; MORTALITY; DISEASE; WOMEN; RISK;
D O I
10.3389/fonc.2023.1150979
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
IntroductionPatients treated with radiotherapy to the chest region are at risk of cardiac sequelae, however, identification of those with greatest risk of complications remains difficult. Here, we sought to determine whether short-term changes in circulating miRNA expression are related to measures of cardiac dysfunction in follow-up. Materials and methodsTwo parallel patient cohorts were enrolled and followed up for 3 years after completion of RT to treat left-sided breast cancer. In the primary group (N=28) we used a a panel of 752 miRNAs to identify miRNAs associated with radiation and cardiac indices at follow up. In the second, independent cohort (N=56) we validated those candidate miRNAs with a targeted qPCR panel. In both cohorts. serum samples were collected before RT, 24h after the last dose and 1 month after RT; cardiac echocardiography was performed 2.5-3 year after RT. ResultsSeven miRNAs in the primary group showed marked changes in serum miRNAs immediately after RT compared to baseline and associations with cardiopulmonary dose-volume histogram metrics. Among those miRNAs: miR-15b-5p, miR-22-3p, miR-424-5p and miR-451a were confirmed to show significant decrease of expression 24 hours post-RT in the validation cohort. Moreover, miR-29c, miR-451 and miR-424 were correlated with the end-diastolic diameter of the left ventricle, which was also confirmed in multivariable analysis adjusting for RT-associated factors. ConclusionWe identified a subset of circulating miRNAs predictive for cardiac function impairment in patients treated for left-sided breast cancer, although longer clinical observation could determine if these can be used to predict major clinical endpoints.
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页数:11
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