Thrombospondin-2 acts as a critical regulator of cartilage regeneration: A review

被引：4
|
作者：
Niu, Jing [1 ,2 ,3 ]
Liu, Yanli [2 ,3 ]
Wang, Junjun [2 ,3 ]
Wang, Hui [2 ,3 ]
Zhao, Ying [2 ,3 ,4 ]
Zhang, Min [2 ,3 ]
机构：
[1] Northwest Univ, Coll Life Sci & Med, Xian, Peoples R China
[2] Fourth Mil Med Univ, Sch Stomatol, State Key Lab Mil Stomatol, Xian 710032, Peoples R China
[3] Fourth Mil Med Univ, Natl Clin Res Ctr Oral Dis, Sch Stomatol, Dept Gen Dent & Emergency, Xian 710032, Peoples R China
[4] Northwest Univ, Xian Peoples Hosp, Xian Hosp 4, Dept Anesthesiol & Perioperat Med, Xian, Peoples R China
来源：
MEDICINE | 2023年 / 102卷 / 17期
基金：
中国国家自然科学基金;
关键词：
articular cartilage; regeneration; repair; thrombospondin-2 (TSP-2); MESENCHYMAL STEM-CELLS; INDUCED SECRETED PROTEIN; CHONDROCYTE DIFFERENTIATION; MATRICELLULAR PROTEIN; ARTICULAR-CARTILAGE; EXPRESSION; OSTEOARTHRITIS; GROWTH; REPAIR; MICE;
D O I：
10.1097/MD.0000000000033651
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The degeneration of articular cartilage tissue is the most common cause of articular cartilage diseases such as osteoarthritis. There are limitations in chondrocyte self-renewal and conventional treatments. During cartilage regeneration and repair, growth factors are typically used to induce cartilage differentiation in stem cells. The role of thrombospondin-2 in cartilage formation has received much attention in recent years. This paper reviews the role of thrombospondin-2 in cartilage regeneration and the important role it plays in protecting cartilage from damage caused by inflammation or trauma and in the regenerative repair of cartilage by binding to different receptors and activating different intracellular signaling pathways. These studies provide new ideas for cartilage repair in clinical settings.
引用
收藏
页数：7
相关论文
共 50 条
  • [41] Absence of Thrombospondin-2 Causes Age-Related Dilated Cardiomyopathy
    Swinnen, Melissa
    Vanhoutte, Davy
    Van Almen, Geert C.
    Hamdani, Nazha
    Schellings, Mark W. M.
    D'hooge, Jan
    Van der Velden, Jolanda
    Weaver, Matthew S.
    Sage, E. Helene
    Bornstein, Paul
    Verheyen, Fons K.
    VandenDriessche, Thierry
    Chuah, Marinee K.
    Westermann, Dirk
    Paulus, Walter J.
    Van de Werf, Frans
    Schroen, Blanche
    Carmeliet, Peter
    Pinto, Yigal M.
    Heymans, Stephane
    CIRCULATION, 2009, 120 (16) : 1585 - U72
  • [42] Absence of thrombospondin-2 increases cardiomyocyte damage and matrix disruption in doxorubicin-induced cardiomyopathy
    van Almen, Geert C.
    Swinnen, Melissa
    Carai, Paolo
    Verhesen, Wouter
    Cleutjens, Jack P. M.
    D'hooge, Jan
    Verheyen, Fons K.
    Pinto, Yigal M.
    Schroen, Blanche
    Carmeliet, Peter
    Heymans, Stephane
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2011, 51 (03) : 318 - 328
  • [43] CCN2: a master regulator of the genesis of bone and cartilage
    Masaharu Takigawa
    Journal of Cell Communication and Signaling, 2013, 7 : 191 - 201
  • [44] CCN2: a master regulator of the genesis of bone and cartilage
    Takigawa, Masaharu
    JOURNAL OF CELL COMMUNICATION AND SIGNALING, 2013, 7 (03) : 191 - 201
  • [45] Thrombospondin-2 acts as a bridge between tumor extracellular matrix and immune infiltration in pancreatic and stomach adenocarcinomas: an integrative pan-cancer analysis
    Liao, Xingchen
    Wang, Wei
    Yu, Baoping
    Tan, Shiyun
    CANCER CELL INTERNATIONAL, 2022, 22 (01)
  • [46] Bombyx mori derived scaffolds and their use in cartilage regeneration: a systematic review
    Fazal, N.
    Latief, N.
    OSTEOARTHRITIS AND CARTILAGE, 2018, 26 (12) : 1583 - 1594
  • [47] Chitosan, hyaluronan and chondroitin sulfate in tissue engineering for cartilage regeneration: A review
    Muzzarelli, Riccardo A. A.
    Greco, Francesco
    Busilacchi, Alberto
    Sollazzo, Vincenzo
    Gigante, Antonio
    CARBOHYDRATE POLYMERS, 2012, 89 (03) : 723 - 739
  • [48] Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review
    Wang, Xianggang
    Li, Zuhao
    Wang, Chenyu
    Bai, Haotian
    Wang, Zhonghan
    Liu, Yuzhe
    Bao, Yirui
    Ren, Ming
    Liu, He
    Wang, Jincheng
    FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2021, 9
  • [49] Glycosphingolipids in Osteoarthritis and Cartilage-Regeneration Therapy: Mechanisms and Therapeutic Prospects Based on a Narrative Review of the Literature
    Homan, Kentaro
    Onodera, Tomohiro
    Matsuoka, Masatake
    Iwasaki, Norimasa
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (09)
  • [50] A Review On Use Of Polymeric Hydrogel For Cartilage Regeneration
    Jebasurya, D.
    Arjun, Uppuluri Varuna Naga Venkata
    Shanmugarajan, T. S.
    INTERNATIONAL JOURNAL OF LIFE SCIENCE AND PHARMA RESEARCH, 2020, 11 (02):
12345