Enhancing oral delivery of plant-derived vesicles for colitis

被引：9

作者：

Liu, Yuan ^{[1
,2
]}

Ahumada, Adrian Lankenau ^{[1
,2
]}

Bayraktar, Emine ^{[1
]}

Schwartz, Paul ^{[1
]}

Chowdhury, Mamur ^{[1
]}

Shi, Sixiang ^{[1
]}

Sebastian, Manu M. ^{[3
]}

Khant, Htet ^{[4
,5
]}

de Val, Natalia ^{[4
,5
]}

Bayram, Nazende Nur ^{[1
]}

Zhang, Guodong ^{[9
]}

Vu, Thanh Chung ^{[1
]}

Jie, Zuliang ^{[6
]}

Jennings, Nicholas B. ^{[1
]}

-Aguayo, Cristian Rodriguez ^{[7
,8
]}

Swain, Jody ^{[3
]}

Stur, Elaine ^{[1
]}

Mangala, Lingegowda S. ^{[1
]}

Wu, Yutuan ^{[1
]}

Nagaraju, Supriya ^{[1
]}

Ermias, Brooke ^{[1
]}

Li, Chun ^{[9
]}

Lopez-Berestein, Gabriel ^{[7
,8
]}

Braam, Janet ^{[2
]}

Sood, Anil K. ^{[1
,8
,10
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol & Reprod Med, Houston, TX 77030 USA

[2] Rice Univ, Dept Biosci, Houston, TX 77005 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Vet Med & Surg, Div Basic Sci, Houston, TX 77030 USA

[4] NCI, Ctr Mol Microscopy, Ctr Canc Res, Frederick, MD 21702 USA

[5] Leidos Biomed Inc, Frederick Natl Lab Canc Res, Canc Res Technol Program, Frederick, MD 21702 USA

[6] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

[7] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA

[8] Univ Texas MD Anderson Canc Ctr, Ctr RNA Interference & Noncoding RNA, Houston, TX 77030 USA

[9] Univ Texas MD Anderson Canc Ctr, Canc Syst Imaging, Houston, TX 77030 USA

[10] Dept Gynecol Oncol & Reprod Med, Unit 1362,1515 Holcombe Blvd, Houston, TX 77030 USA

来源：

JOURNAL OF CONTROLLED RELEASE | 2023年 / 357卷

基金：

美国国家卫生研究院;

关键词：

Oral delivery; Plant -derived vesicles; Eudragit S100 coat; Lyophilization; Vesicle stability; Gastrointestinal tract; METHACRYLIC-ACID COPOLYMERS; DRUG-DELIVERY; NANOPARTICLES; INDOLE-3-CARBINOL; NANOVESICLES; MANIPULATION; MICE;

D O I：

10.1016/j.jconrel.2023.03.056

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Plant-derived vesicles (PDVs) are attractive for therapeutic applications, including as potential nanocarriers. However, a concern with oral delivery of PDVs is whether they would remain intact in the gastrointestinal tract. We found that 82% of cabbage PDVs were destroyed under conditions mimicking the upper digestive tract. To overcome this limitation, we developed a delivery method whereby lyophilized Eudragit S100-coated cabbage PDVs were packaged into a capsule (Cap-cPDVs). Lyophilization and suspension of PDVs did not have an appreciable impact on PDV structure, number, or therapeutic effect. Additionally, packaging the lyophilized Eudragit S100-coated PDVs into capsules allowed them to pass through the upper gastrointestinal tract for delivery into the colon better than did suspension of PDVs in phosphate-buffered saline. Cap-cPDVs showed robust therapeutic effect in a dextran sulfate sodium-induced colitis mouse model. These findings could have broad implications for the use of PDVs as orally delivered nanocarriers of natural therapeutic plant compounds or other therapeutics.

引用

页码：472 / 483

页数：12

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