Modified Bacteriophage for Tumor Detection and Targeted Therapy

被引：9
|
作者：
Shen, Yuanzhao [1 ,2 ,3 ]
Wang, Jingyu [1 ]
Li, Yuting [1 ]
Yang, Chih-Tsung [4 ]
Zhou, Xin [1 ,2 ,3 ]
机构：
[1] Yangzhou Univ, Inst Comparat Med, Coll Vet Med, Yangzhou 225009, Peoples R China
[2] Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Peoples R China
[3] Yangzhou Univ, Joint Int Res Lab Agr & Agriprod Safety, Minist Educ China, Yangzhou 225009, Peoples R China
[4] Univ South Australia, Future Ind Inst, Mawson Lakes Campus, Adelaide, SA 5095, Australia
来源：
NANOMATERIALS | 2023年 / 13卷 / 04期
基金：
中国国家自然科学基金;
关键词：
bacteriophage (phage); genetically engineered phages; phage display; chemical modification; biological detection; tumor screening; targeted therapy; SITE-SPECIFIC RECOMBINATION; PHAGE DISPLAY; METABOLIC INCORPORATION; IN-VITRO; ENVELOPED VIRUS; CANCER; PROTEINS; PEPTIDES; BINDING; M13;
D O I：
10.3390/nano13040665
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Malignant tumor is one of the leading causes of death in human beings. In recent years, bacteriophages (phages), a natural bacterial virus, have been genetically engineered for use as a probe for the detection of antigens that are highly expressed in tumor cells and as an anti-tumor reagent. Furthermore, phages can also be chemically modified and assembled with a variety of nanoparticles to form a new organic/inorganic composite, thus extending the application of phages in biological detection and tumor therapeutic. This review summarizes the studies on genetically engineered and chemically modified phages in the diagnosis and targeting therapy of tumors in recent years. We discuss the advantages and limitations of modified phages in practical applications and propose suitable application scenarios based on these modified phages.
引用
收藏
页数：18
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