A Biodegradable Antigen Nanocapsule Promotes Anti-Tumor Immunity via the cGAS-STING Pathway

被引：9

作者：

Jia, Xiangqian ^{[1
,2
,3
]}

Chen, Hang ^{[1
]}

Wu, Mengling ^{[1
]}

Wang, Luyao ^{[1
]}

Li, Tiantian ^{[1
]}

Ma, Jing ^{[1
]}

Yi, Xueqing ^{[1
]}

Tan, Pengcheng ^{[1
]}

Zheng, Peiyuan ^{[1
]}

Du, Juanjuan ^{[1
]}

机构：

[1] Tsinghua Univ, Sch Pharmaceut Sci, MOE Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 10084, Peoples R China

[2] Heilongjiang Univ, Engn Res Ctr Agr Microbiol Technol, Minist Educ, Harbin 150500, Peoples R China

[3] Heilongjiang Univ, Coll Heilongjiang Prov, Sch Life Sci, Key Lab Microbiol, Harbin 150080, Peoples R China

来源：

ADVANCED FUNCTIONAL MATERIALS | 2023年 / 33卷 / 10期

基金：

国家重点研发计划;

关键词：

antigen nanocapsules; cancer vaccines; cGAS-STING pathway; in situ polymerization; nanovaccines; I INTERFERONS; CANCER; NANOPARTICLES; INDUCTION; TRAFFICKING; MECHANISMS; EXPRESSION; GLYPICAN-3; ADJUVANTS;

D O I：

10.1002/adfm.202212085

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Materials-based antigen delivery systems can augment the immune response by improving antigen uptake in antigen-presenting cells, targeting lymph nodes, prolonging antigen exposure, enhancing cross-presentation, etc. Recent research revealed that some antigen carriers activate the innate immune pathways without additional adjuvant. Here, a vaccine delivery platform (antigen nanocapsules) constructed by a one-step in situ polymerization is reported, weaving a biodegradable polymer network around the antigen surface. This simple technology allowed us to study the immunomodulatory effect of various antigen carriers. An antigen nanocapsule (NC7) capable of inducing dendritic cell activation and cross-presentation is identified. Further mechanistic studies revealed that NC7 activated the cGAS-STING pathway in a cGAS-dependent manner. Moreover, the subcutaneously injected NC7 accumulated in the lymph nodes and elicited strong cytotoxic T cell immunity and T cell memory against established cancer. Collectively, the often-neglected immunomodulatory effect of various cationic antigen carriers, enabling potential application in cancer vaccines, is uncovered.

引用

页数：12

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