Exosomal lncRNA HOTAIR promotes osteoclast differentiation by targeting TGF-β/PTHrP/RANKL pathway

被引：8
作者：
Zhang, Chengcheng [1 ,2 ]
Yang, Jiyong [3 ]
Zhu, Zhiyao [1 ,2 ]
Qin, Jingru [1 ]
Yang, Lu [1 ]
Zhao, Xiaoxue [1 ,2 ]
Su, Wan [1 ]
Cai, Yuejiao [1 ]
Yang, Jia [1 ]
Wang, Fengying [2 ]
Chen, Wenlian [2 ]
Gu, Honggang [4 ]
Deng, Haibin [1 ,5 ]
Wang, Zhongqi [1 ,5 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Med Oncol, Shanghai, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Canc Inst, Shanghai, Peoples R China
[3] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Hepatobiliary Surg, Shanghai, Peoples R China
[4] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Hepatobiliary Surg, 725 Wanpingnan Rd, Shanghai 200032, Peoples R China
[5] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Med Oncol, 725 Wanpingnan Rd, Shanghai 200032, Peoples R China
来源：
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY | 2023年 / 132卷 / 03期
基金：
中国国家自然科学基金;
关键词：
exosomes; lncRNA HOTAIR; lung cancer; osteoclast differentiation; PTHrP; RANKL; TGF-beta; CANCER; RANKL;
D O I：
10.1111/bcpt.13823
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Bone tissue is a common metastatic site of lung cancer, and bone metastasis is characterized by abnormal differentiation and malfunction of osteoclast, and the roles of exosomes derived from lung cancer have attracted much attention. In our study, we found that the level of HOTAIR expression in A549 and H1299 exosomes was higher than those of normal lung fibrocytes. Overexpression of HOTAIR in A549 and H1299 exosomes promoted osteoclast differentiation. Furthermore, A549-Exos and H1299-Exos targeted bone tissues, and bone formation was significantly inhibited in vivo. Mechanistically, exosomal lncRNA HOTAIR promoted bone resorption by targeting TGF-beta/PTHrP/RANKL pathway.
引用
收藏
页码：242 / 252
页数：11
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