Pd-catalyzed access to mono- and di-fluoroallylic amines from primary anilines

被引：12

作者：

Wang, Xingben ^{[1
]}

Patureau, Frederic W. ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 04期

关键词：

ALLYLIC ALCOHOLS; DIRECT AMINATION; DESIGN; ACIDS;

D O I：

10.1039/d2cc05844h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Pd-catalyzed highly selective synthesis of mono- and di-2-fluoroallylic amines from gem-difluorocyclopropanes and ubiquitous unprotected primary anilines is herein described. Initial kinetic investigations suggest a first order in the gem-difluorocyclopropane substrate, as well as a circa zeroth order in the aniline coupling partner. The newly produced fluoroallylic motifs should find important applications in synthetic as well as medicinal chemistry and stimulate the further development of coupling methods based on strained cyclic building blocks.

引用

页码：486 / 489

页数：4

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