L-Aspartic acid pyridinium salts: In silico, synthesis and adjuvant vs antibiotic antibacterial evaluation

被引：0

作者：

Cano, Jessica R. Gutierrez ^{[1
]}

Morales-Sandoval, I. Paulina ^{[2
,3
]}

Gnecco, Dino ^{[1
]}

Carrasco-Carballo, Alan ^{[1
,2
,4
]}

Teran, Joel L. ^{[1
]}

机构：

[1] Benemerita Univ Autonoma Puebla, Ctr Quim, Lab Sintesis Organ, Inst Ciencias, Edif IC9,Complejo Ciencias,CU, Puebla, Pue, Mexico

[2] Benemerita Univ Autonoma Puebla, Lab Elucidac & Sintesis Quim Organ, Inst Ciencias, Puebla, Mexico

[3] Benemerita Univ Autonoma Puebla, Jardin Bot Univ, Puebla, Pue, Mexico

[4] Benemerita Univ Autonoma Puebla, CONAHCYT, CU, Puebla, Pue, Mexico

来源：

RESULTS IN CHEMISTRY | 2024年 / 7卷

关键词：

L -Aspartic acid; Pyridinium salts; Adjuvant; Antibiotic; Molecular docking; CRYSTAL-STRUCTURE; DERIVATIVES; ALKYLATION;

D O I：

10.1016/j.rechem.2024.101366

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the present study, a new series of chiral L-aspartic acid pyridinium salts have been designed, guided by molecular docking as antiemetics via TrySR or DNA GryB inhibitors, as well as an adjuvant to chloramphenicol via CAT-III inhibitor to continue with antibacterial in vitro study. Newly designed molecules have been synthesized by chemistry route and their characterization was done by using NMR & HRMS techniques. Biological evaluation of synthesized compounds has been done on Gram-negative bacteria, to E. coli The in vitro evaluation results have shown that pyridinium salts 3a, 3e, 3i, 3j, 3k and 3o as an antibacterial, in addition to 3o and 3i, as an adjuvant against E. coli resistant to chloramphenicol.

引用

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