Protective Effect of Lycopene against Ethanol-induced Oxidative Kidney Damage in Rats

被引：0

作者：

Yilmaz, Canan Tuz ^{[1
]}

Suleyman, Bahadir ^{[2
]}

Mammadov, Renad ^{[2
]}

Bulut, Seval ^{[2
]}

Gursul, Cebrail ^{[3
]}

Yazici, Gulce Naz ^{[4
]}

Gulaboglu, Mine ^{[5
]}

Suleyman, Halis ^{[2
]}

机构：

[1] Bursa Uludag Univ, Fac Med, Dept Family Med, TR-16059 Bursa, Turkiye

[2] Erzincan Binali Yildirim Univ, Fac Med, Dept Pharmacol, TR-24100 Erzincan, Turkiye

[3] Erzincan Binali Yildirim Univ, Fac Med, Dept Physiol, TR-24100 Erzincan, Turkiye

[4] Erzincan Binali Yildirim Univ, Fac Med, Dept Histol & Embryol, TR-24100 Erzincan, Turkiye

[5] Erzurum Ataturk Univ, Fac Pharm, Dept Biochem, TR-25240 Erzurum, Turkiye

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2023年 / 42卷 / 12期

关键词：

ethanol; lycopene; oxidative damage; renal damage; SATIVA FIXED OIL; TOXICITY; STRESS; GLUTATHIONE; TISSUES; INJURY;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Alcohol consumption can have dramatic effects on organs and tissue cells, with kidneys being some of the most affected organs. This study investigates the effect of lycopene on ethanol -induced oxidative kidney damage in rats. Albino Wistar rats were randomly divided into three groups. The first group served as the healthy group (HG), receiving distilled water as a solvent; the second group was the ethanol group (EtON), receiving only ethanol; the third group received both lycopene and ethanol (LEt). While ethanol administration increased malondialdehyde (MDA), total oxidant status (TOS), and oxidative stress index (OSI) levels, it caused a decrease in total glutathione (tGSH) and total antioxidant status (TAS) levels. Also, ethanol caused histopathological damage to the kidney. It has been observed that lycopene inhibits ethanol -induced biochemical and histopathological changes in kidney tissue. Lycopene inhibited the change in the oxidant -antioxidant balance towards oxidants under ethanol treatment and prevented ethanol -associated kidney oxidative damage.

引用

页码：2417 / 2422

页数：6

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