Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer

被引:9
|
作者
Kurowska, Natalia [1 ]
Madej, Marcel [1 ,2 ]
Strzalka-Mrozik, Barbara [1 ]
机构
[1] Med Univ Siles, Fac Pharmaceut Sci Sosnowiec, Dept Mol Biol, PL-40055 Katowice, Poland
[2] Med Univ Silesia, Ctr Res & Implementat, Siles LabMed, PL-40752 Katowice, Poland
关键词
Nigella sativa; thymoquinone; colorectal cancer; adjuvant therapy; anticancer therapy; 5-FU resistance; NIGELLA-SATIVA L; LOVO COLON-CANCER; ANTICANCER THYMOQUINONE; OXIDATIVE STRESS; CELL-DEATH; APOPTOSIS; EXTRACTION; 5-FLUOROURACIL; INHIBITION; SEEDS;
D O I
10.3390/cimb46010010
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and is responsible for approximately one million deaths each year. The current standard of care is surgical resection of the lesion and chemotherapy with 5-fluorouracil (5-FU). However, of concern is the increasing incidence in an increasingly younger patient population and the ability of CRC cells to develop resistance to 5-FU. In this review, we discuss the effects of thymoquinone (TQ), one of the main bioactive components of Nigella sativa seeds, on CRC, with a particular focus on the use of TQ in combination therapy with other chemotherapeutic agents. TQ exhibits anti-CRC activity by inducing a proapoptotic effect and inhibiting proliferation, primarily through its effect on the regulation of signaling pathways crucial for tumor progression and oxidative stress. TQ can be used synergistically with chemotherapeutic agents to enhance their anticancer effects and to influence the expression of signaling pathways and other genes important in cancer development. These data appear to be most relevant for co-treatment with 5-FU. We believe that TQ is a suitable candidate for consideration in the chemoprevention and adjuvant therapy for CRC, but further studies, including clinical trials, are needed to confirm its safety and efficacy in the treatment of cancer.
引用
收藏
页码:121 / 139
页数:19
相关论文
共 50 条
  • [31] Harnessing Ferroptosis to Overcome Drug Resistance in Colorectal Cancer: Promising Therapeutic Approaches
    Cheng, Xiaofei
    Zhao, Feng
    Ke, Bingxin
    Chen, Dong
    Liu, Fanlong
    CANCERS, 2023, 15 (21)
  • [32] Significant position of C-myc in colorectal cancer: a promising therapeutic target
    Tan, Li
    Peng, Dong
    Cheng, Yong
    CLINICAL & TRANSLATIONAL ONCOLOGY, 2022, 24 (12): : 2295 - 2304
  • [33] Dual inhibition of BDNF/TrkB and autophagy: a promising therapeutic approach for colorectal cancer
    Mazouffre, Clement
    Geyl, Sophie
    Perraud, Aurelie
    Blondy, Sabrina
    Jauberteau, Marie-Odile
    Mathonnet, Muriel
    Verdier, Mireille
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2017, 21 (10) : 2610 - 2622
  • [34] A Study on Thymoquinone: Antioxidant Capacity and Anticancer Activities in LoVo Colorectal Cancer Cells
    Bozali, Kubra
    Metin Guler, Eray
    Kocyigit, Abdurrahim
    CHEMISTRY & BIODIVERSITY, 2024, 21 (02)
  • [35] New class of hybrids based on chalcone and melatonin: a promising therapeutic option for the treatment of colorectal cancer
    Andrés F. Yepes
    Juan D. Arias
    Wilson Cardona-G
    Angie Herrera-R
    Gustavo Moreno
    Medicinal Chemistry Research, 2021, 30 : 2240 - 2255
  • [36] Astaxanthin: A promising therapeutic agent for organ fibrosis
    Li, Ke
    Wang, Wenhong
    Xiao, Weihua
    PHARMACOLOGICAL RESEARCH, 2023, 188
  • [37] Apoptotic pathways as a therapeutic target for colorectal cancer treatment
    Aman M Abraha
    Ezra B Ketema
    World Journal of Gastrointestinal Oncology, 2016, (08) : 583 - 591
  • [38] Therapeutic efficacy of ferroptosis in the treatment of colorectal cancer (Review)
    Guo, Zhao
    Zhuang, Haoyan
    Shi, Xuewen
    ONCOLOGY LETTERS, 2024, 28 (06)
  • [39] Polyphenol Oxidase as a Promising Alternative Therapeutic Agent for Cancer Therapy
    Yuan, Qinqin
    Guo, Huixia
    Ding, Jiajie
    Jiao, Chan
    Qi, Yalei
    Zafar, Hajra
    Ma, Xueyun
    Raza, Faisal
    Han, Jianqiu
    MOLECULES, 2022, 27 (05):
  • [40] Synergistic Anti-Cancer Effects of Curcumin and Thymoquinone Against Melanoma
    Mohd, Hana
    Michniak-Kohn, Bozena
    ANTIOXIDANTS, 2024, 13 (12)