Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer

被引:9
|
作者
Kurowska, Natalia [1 ]
Madej, Marcel [1 ,2 ]
Strzalka-Mrozik, Barbara [1 ]
机构
[1] Med Univ Siles, Fac Pharmaceut Sci Sosnowiec, Dept Mol Biol, PL-40055 Katowice, Poland
[2] Med Univ Silesia, Ctr Res & Implementat, Siles LabMed, PL-40752 Katowice, Poland
关键词
Nigella sativa; thymoquinone; colorectal cancer; adjuvant therapy; anticancer therapy; 5-FU resistance; NIGELLA-SATIVA L; LOVO COLON-CANCER; ANTICANCER THYMOQUINONE; OXIDATIVE STRESS; CELL-DEATH; APOPTOSIS; EXTRACTION; 5-FLUOROURACIL; INHIBITION; SEEDS;
D O I
10.3390/cimb46010010
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and is responsible for approximately one million deaths each year. The current standard of care is surgical resection of the lesion and chemotherapy with 5-fluorouracil (5-FU). However, of concern is the increasing incidence in an increasingly younger patient population and the ability of CRC cells to develop resistance to 5-FU. In this review, we discuss the effects of thymoquinone (TQ), one of the main bioactive components of Nigella sativa seeds, on CRC, with a particular focus on the use of TQ in combination therapy with other chemotherapeutic agents. TQ exhibits anti-CRC activity by inducing a proapoptotic effect and inhibiting proliferation, primarily through its effect on the regulation of signaling pathways crucial for tumor progression and oxidative stress. TQ can be used synergistically with chemotherapeutic agents to enhance their anticancer effects and to influence the expression of signaling pathways and other genes important in cancer development. These data appear to be most relevant for co-treatment with 5-FU. We believe that TQ is a suitable candidate for consideration in the chemoprevention and adjuvant therapy for CRC, but further studies, including clinical trials, are needed to confirm its safety and efficacy in the treatment of cancer.
引用
收藏
页码:121 / 139
页数:19
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