Self-assembling peptides: Perspectives regarding biotechnological applications and vaccine development

被引:5
作者
Reyes, Cesar [1 ,2 ,3 ]
Patarroyo, Manuel A. [4 ,5 ]
机构
[1] Univ Nacl Colombia, Fac Sci, PhD Biotechnol Programme, Carrera 45 26-85, Bogota 111321, Colombia
[2] Fdn Inst Inmunol Colombia FIDIC, Struct Anal Dept, Carrera 50 26-20, Bogota 111321, Colombia
[3] Univ Ciencias Aplicadas & Ambientales UDCA, Anim Sci Fac, Calle 222 55-37, Bogota 111166, Colombia
[4] Fdn Inst Inmunol Colombia FIDIC, Mol Biol & Immunol Dept, Carrera 50 26-20, Bogota 111321, Colombia
[5] Univ Nacl Colombia, Fac Med, Microbiol Dept, Carrera 45 26-85, Bogota 111321, Colombia
关键词
Self; -assembly; Supramolecular structure; Biotechnology; Delivery system; Adjuvant; Vaccine development; BETA-SHEET; ANTIMICROBIAL PEPTIDES; BIOLOGICAL-MATERIALS; DRUG-DELIVERY; DESIGN; ADJUVANTS; OLIGOPEPTIDE; NANOSTRUCTURES; PROTECTION; VIRUS;
D O I
10.1016/j.ijbiomac.2023.128944
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Self-assembly involves a set of molecules spontaneously interacting in a highly coordinated and dynamic manner to form a specific supramolecular structure having new and clearly defined properties. Many examples of this occur in nature and many more came from research laboratories, with their number increasing every day via ongoing research concerning complex biomolecules and the possibility of harnessing it when developing new applications. As a phenomenon, self-assembly has been described on very different types of molecules (biomolecules including), so this review focuses on what is known about peptide self-assembly, its origins, the forces behind it, how the properties of the resulting material can be tuned in relation to experimental considerations, some biotechnological applications (in which the main protagonists are peptide sequences capable of selfassembly) and what is yet to be tuned regarding their research and development.
引用
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页数:15
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