Assessing the Toxicity of Benzotriazole Ultraviolet Stabilizers to Fishes: Insights into Aryl Hydrocarbon Receptor-Mediated Effects

被引:10
作者
Johnson, Hunter M. [1 ]
Dubiel, Justin [1 ]
Collins, Cameron H. [2 ]
Eriksson, Andreas N. M. [1 ]
Lu, Zhe [3 ]
Doering, Jon A. [1 ,2 ]
Wiseman, Steve [1 ]
机构
[1] Univ Lethbridge, Dept Biol Sci, Lethbridge, AB T1K 3M4, Canada
[2] Louisiana State Univ, Coll Coast & Environm, Dept Environm Sci, Baton Rouge, LA 70803 USA
[3] Univ Quebec Rimouski, Inst Sci Mer Rimouski, Rimouski, PQ G5L 3A1, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
species sensitivity; embryotoxicity; quantitativeadverse outcome pathway; AhR; CYP1A; microinjection; plastics-associated chemicals; SUBSTITUTED DIPHENYLAMINE ANTIOXIDANTS; UV-STABILIZERS; ANTIANDROGENIC ACTIVITY; EQUIVALENCY FACTORS; BLOOD-PLASMA; AH RECEPTOR; IN-VITRO; DIOXIN; SENSITIVITY; WATER;
D O I
10.1021/acs.est.3c06117
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Benzotriazole ultraviolet stabilizers (BUVSs) are chemicals used to mitigate UV-induced damage to manufactured goods. Their presence in aquatic environments and biota raises concerns, as certain BUVSs activate the aryl hydrocarbon receptor (AhR), which is linked to adverse effects in fish. However, potencies of BUVSs as AhR agonists and species sensitivities to AhR activation are poorly understood. This study evaluated the toxicity of three BUVSs using embryotoxicity assays. Zebrafish (Danio rerio) embryos exposed to BUVSs by microinjection suffered dose-dependent increases in mortality, with LD50 values of 4772, 11 608, and 56 292 ng/g-egg for UV-P, UV-9, and UV-090, respectively. The potencies and species sensitivities to AhR2 activation by BUVSs were assessed using a luciferase reporter gene assay with COS-7 cells transfected with the AhR2 of zebrafish and eight other fishes. The rank order of potency for activation of the AhR2 from all nine species was UV-P > UV-9 > UV-090. However, AhR2s among species differed in sensitivities to activation by up to 100-fold. An approximate reversed rank order of species sensitivity was observed compared to the rank order of sensitivity to 2,3,7,8-tetrachlorodibenzo-[p]-dioxin, the prototypical AhR agonist. Despite this, a pre-existing quantitative adverse outcome pathway linking AhR activation to embryo lethality could predict embryotoxicities of BUVSs in zebrafish.
引用
收藏
页码:110 / 120
页数:11
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