Rhodium-Catalyzed Asymmetric Functionalization of Quinoxalinium Salts

被引：3

作者：

Ortiz, Kacey G. ^{[1
]}

Hammons, Jensen S. ^{[1
]}

Karimov, Rashad R. ^{[1
]}

机构：

[1] Auburn Univ, Dept Chem & Biochem, Auburn, AL 36849 USA

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 50期

基金：

美国国家卫生研究院;

关键词：

ENANTIOSELECTIVE ADDITION; NUCLEOPHILIC DEAROMATIZATION; HYDROGENATION; PYRIDINES; ARYLATION; POTENT; TETRAHYDROQUINOXALINES; DERIVATIVES; INHIBITORS; DISCOVERY;

D O I：

10.1021/acs.orglett.3c03555

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a rhodium-catalyzed asymmetric addition of aryl and alkenyl boronic acids to quinoxalinium salts that generates dihydroquinoxalines with high enantioselectivity. Functionalization of the reaction products, dihydroquinoxaline, allows the preparation of tetrahydroquinoxalines with various substitution patterns.

引用

页码：8987 / 8991

页数：5

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