Plasma neurofilament light chain in association to late-life depression in the general population

被引:11
作者
Schuurmans, Isabel K. [1 ,2 ]
Ghanbari, Mohsen [1 ]
Cecil, Charlotte A. M. [1 ,3 ,4 ]
Ikram, M. Arfan [1 ]
Luik, Annemarie I. [1 ,5 ]
机构
[1] Erasmus MC, Univ Med Ctr Rotterdam, Dept Epidemiol, Rotterdam, Netherlands
[2] Erasmus MC, Univ Med Ctr Rotterdam, Generat R Study Grp, Rotterdam, Netherlands
[3] Erasmus MC, Univ Med Ctr Rotterdam, Dept Child & Adolescent Psychiat & Psychol, Rotterdam, Netherlands
[4] Leiden Univ, Med Ctr, Dept Biomed Data Sci, Mol Epidemiol, Leiden, Netherlands
[5] Trimbos Inst Netherlands Inst Mental Hlth & Addict, Utrecht, Netherlands
关键词
biomarkers; depression; middle aged; aged; neurology; AMYLOID-BETA LEVELS; ALZHEIMERS-DISEASE; MAJOR DEPRESSION; METAANALYSIS; BEHAVIORS; BIOMARKER; SYMPTOMS; DEMENTIA; DISORDER; OBESITY;
D O I
10.1111/pcn.13608
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Aim: Investigating what is underlying late-life depression is becoming increasingly important with the rapidly growing elderly population. Yet, the associations between plasma biomarkers of neuroaxonal damage and late-life depression remain largely unclear. Therefore, we determined cross-sectional and longitudinal associations of neurofilament light chain (NfL) with depression in middle-aged and elderly individuals, and total tau, beta-amyloid 40 and 42 for comparison.Methods: We included 3,895 participants (71.78 years [SD = 7.37], 53.4% women) from the population-based Rotterdam Study. Between 2002 and 2005, NfL, total tau, beta-amyloid 40 and beta-amyloid 42 were determined in blood and depressive symptoms were measured with the Center for Epidemiologic Studies Depression scale (CES-D). Incident depressive events (clinically relevant depressive symptoms, depressive syndromes, major depressive disorders) were measured prospectively with the Center for Epidemiologic Studies Depression, a clinical interview and follow-up of medical records over a median follow-up of 7.0 years (interquartile range 1.80). We used linear and Cox proportional hazard regression models.Results: Each log2 pg./mL increase in NfL was cross-sectionally associated with more depressive symptoms (adjusted mean difference: 0.32, 95% CI 0.05-0.58), as well as with an increased risk of any incident depressive event over time (hazard ratio: 1.22, 95% CI 1.01-1.47). Further, more amyloid-beta 40 was cross-sectionally associated with more depressive symptoms (adjusted mean difference: 0.70, 95% CI 0.15-1.25).Conclusion: Higher levels of NfL are cross-sectionally associated with more depressive symptoms and a higher risk of incident depressive events longitudinally. The association was stronger for NfL compared to other plasma biomarkers, suggesting a potential role of neuroaxonal damage in developing late-life depression.
引用
收藏
页码:97 / 103
页数:7
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