Are Selected Cytokines and Epstein-Barr Virus DNA Load Predictors of Hepatological Complications of Epstein-Barr Virus Infection in Children?

被引：0
作者：
Moppert, Justyna [1 ,2 ]
Domagalski, Krzysztof [3 ]
Wrotek, Sylwia [3 ]
Pawlowska, Malgorzata [1 ,2 ]
机构：
[1] Nicolaus Copernicus Univ Torun, Dept Infect Dis & Hepatol, Coll Med Bydgoszcz, PL-87100 Torun, Poland
[2] Voivodeship Infect Observat Hosp Bydgoszcz, Dept Paediat Infect Dis & Hepatol, PL-85030 Bydgoszcz, Poland
[3] Nicolaus Copernicus Univ Torun, Fac Biol & Vet Sci, Dept Immunol, PL-87100 Torun, Poland
来源：
JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 19期
关键词：
EBV infection; hepatitis; cytokines; EBV DNA load; ACUTE ACALCULOUS CHOLECYSTITIS; ADHESION MOLECULE-1 ICAM-1; LIVER-DISEASE; INTERLEUKIN-6; EXPRESSION; MORTALITY; DIAGNOSIS; ASSAY;
D O I：
10.3390/jcm12196158
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The aim of the study was to evaluate tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), soluble intracellular adhesion molecules 1 (s-ICAM-1) and Epstein-Barr virus (EBV) DNA load levels as predictors of hepatological complications of EBV infection in children. The study group consisted of 54 children aged one to eighteen years, who were hospitalised from 1 December 2018 to 31 December 2020 in the Department of Paediatrics, Infectious Diseases and Hepatology and who had hepatological complications in the course of serologically and molecularly confirmed EBV infection. It was shown that IL-6, TNF-alpha, and s-ICAM-1 concentrations were the highest in patients with hepatitis and biliary pole damage. Higher EBV DNA viremia positively correlated with increased C-reactive protein (CRP) and TNF-alpha levels and increased leukocyte, lymphocyte, and monocyte counts. Increases in lymphocyte counts and TNF-alpha concentrations were observed along with increases in gamma-glutamyl transpeptidase (GGTP) activity. Increased concentrations of IL-6, TNF-alpha, and s-ICAM-1 may indicate the risk of hepatitis with concomitant biliary pole damage during EBV infection.
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页数：11
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