Neutralising antibodies against human metapneumovirus

被引：14

作者：

Guo, Lei ^{[1
]}

Li, Li ^{[1
]}

Liu, Li ^{[1
]}

Zhang, Tiesong ^{[1
]}

Sun, Ming ^{[2
]}

机构：

[1] Kunming Childrens Hosp, Yunnan Inst Pediat, Yunnan Key Lab Childrens Major Dis Res, Kunming 650228, Yunnan, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biol, Kunming, Yunnan, Peoples R China

来源：

LANCET MICROBE | 2023年 / 4卷 / 09期

基金：

中国国家自然科学基金;

关键词：

RESPIRATORY SYNCYTIAL VIRUS; HUMAN MONOCLONAL-ANTIBODY; FUSION PROTEIN; MEMBRANE-FUSION; INFLUENZA-VIRUS; F-PROTEIN; IN-VITRO; INFECTION; VACCINE; CHILDREN;

D O I：

10.1016/S2666-5247(23)00134-9

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Human metapneumovirus (hMPV) is one of the leading causes of respiratory infection. Since its discovery in 2001, no specific antiviral or vaccine has been available in contrast to its closely related family member human respiratory syncytial virus (hRSV). Neutralising monoclonal antibodies (nMAbs) are the core effectors of vaccines and are essential therapeutic immune drugs against infectious pathogens. The development of nMAbs against hMPV has accelerated in recent years as a result of breakthroughs in viral fusion (F) protein structural biology and experience with hRSV and other enveloped viruses. We provide an overview of the potent F-specific nMAbs of hMPV, generalise their targeting F antigen epitopes, and discuss the nMAb development strategy and future directions for hMPV and broad-spectrum hMPV, hRSV nMabs, and vaccine research and development.

引用

页码：E732 / E744

页数：13

共 74 条

[1] Taxonomy of the order Mononegavirales: update 2019 [J].

Amarasinghe, Gaya K. ;

Ayllon, Maria A. ;

Bao, Yiming ;

Basler, Christopher F. ;

Bavari, Sina ;

Blasdell, Kim R. ;

Briese, Thomas ;

Brown, Paul A. ;

Bukreyev, Alexander ;

Balkema-Buschmann, Anne ;

Buchholz, Ursula J. ;

Chabi-Jesus, Camila ;

Chandran, Kartik ;

Chiapponi, Chiara ;

Crozier, Ian ;

de Swart, Rik L. ;

Dietzgen, Ralf G. ;

Dolnik, Olga ;

Drexler, Jan F. ;

Duerrwald, Ralf ;

Dundon, William G. ;

Duprex, W. Paul ;

Dye, John M. ;

Easton, Andrew J. ;

Fooks, Anthony R. ;

Formenty, Pierre B. H. ;

Fouchier, Ron A. M. ;

Freitas-Astua, Juliana ;

Griffiths, Anthony ;

Hewson, Roger ;

Horie, Masayuki ;

Hyndman, Timothy H. ;

Jiang, Daohong ;

Kitajima, Elliott W. ;

Kobinger, Gary P. ;

Kondo, Hideki ;

Kurath, Gael ;

Kuzmin, Ivan V. ;

Lamb, Robert A. ;

Lavazza, Antonio ;

Lee, Benhur ;

Lelli, Davide ;

Leroy, Eric M. ;

Li, Jianrong ;

Maes, Piet ;

Marzano, Shin-Yi L. ;

Moreno, Ana ;

Muhlberger, Elke ;

Netesov, Sergey V. ;

Nowotny, Norbert .

ARCHIVES OF VIROLOGY, 2019, 164 (07) :1967-1980

[2] Safety and Immunogenicity of an mRNA-Based Human Metapneumovirus and Parainfluenza Virus Type 3 Combined Vaccine in Healthy Adults [J].

August, Allison ;

Shaw, Christine A. ;

Lee, Heather ;

Knightly, Conor ;

Kalidindia, Shiva ;

Chu, Laurence ;

Essink, Brandon J. ;

Seger, William ;

Zaks, Tal ;

Smolenov, Igor ;

Panther, Lori .

OPEN FORUM INFECTIOUS DISEASES, 2022, 9 (07)

[3] Structural basis for ultrapotent antibody-mediated neutralization of human metapneumovirus [J].

Banerjee, Avik ;

Huang, Jiachen ;

Rush, Scott A. ;

Murray, Jackelyn ;

Gingerich, Aaron D. ;

Royer, Fredejah ;

Hsieh, Ching-Lin ;

Tripp, Ralph A. ;

McLellan, Jason S. ;

Mousa, Jarrod J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 119 (25)

[4] A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface [J].

Bangaru, Sandhya ;

Lang, Shanshan ;

Schotsaert, Michael ;

Vanderven, Hillary A. ;

Zhu, Xueyong ;

Kose, Nurgun ;

Bombardi, Robin ;

Finn, Jessica A. ;

Kent, Stephen J. ;

Gilchuk, Pavlo ;

Gilchuk, Iuliia ;

Turner, Hannah L. ;

Garcia-Sastre, Adolfo ;

Li, Sheng ;

Ward, Andrew B. ;

Wilson, Ian A. ;

Crowe, James E., Jr. .

CELL, 2019, 177 (05) :1136-+

[5] A Potent Neutralizing Site III-Specific Human Antibody Neutralizes Human Metapneumovirus In Vivo [J].

Bar-Peled, Yael ;

Diaz, Darren ;

Pena-Briseno, Alma ;

Murray, Jackelyn ;

Huang, Jiachen ;

Tripp, Ralph A. ;

Mousa, Jarrod J. .

JOURNAL OF VIROLOGY, 2019, 93 (19)

[6] Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein [J].

Battles, Michael B. ;

Mas, Vicente ;

Olmedillas, Eduardo ;

Cano, Olga ;

Vazquez, Monica ;

Rodriguez, Laura ;

Melero, Jose A. ;

McLellan, Jason S. .

NATURE COMMUNICATIONS, 2017, 8

[7] Infection of nonhuman primates with recombinant human metapneumovirus lacking the SH, G, or M2-2 protein categorizes each as a nonessential accessory protein and identifies vaccine candidates [J].

Biacchesi, S ;

Pham, QN ;

Skiadopoulos, MH ;

Murphy, BR ;

Collins, PL ;

Buchholz, UJ .

JOURNAL OF VIROLOGY, 2005, 79 (19) :12608-12613

[8] Recombinant human metapneumovirus lacking the small hydrophobic SH and/or attachment G glycoprotein: Deletion of G yields a promising vaccine candidate [J].

Biacchesi, S ;

Skiadopoulos, MH ;

Yang, LJ ;

Lamirande, EW ;

Tran, KC ;

Murphy, BR ;

Collins, PL ;

Buchholz, UJ .

JOURNAL OF VIROLOGY, 2004, 78 (23) :12877-12887

[9] An outbreak of severe respiratory tract infection due to human metapneumovirus in a long-term care facility [J].

Boivin, Guy ;

De Serres, Gaston ;

Hamelin, Marie-Eve ;

Cote, Stephanie ;

Argouin, Marco ;

Tremblay, Genevieve ;

Maranda-Aubut, Renee ;

Sauvageau, Chantal ;

Ouakki, Manale ;

Boulianne, Nicole ;

Couture, Christian .

CLINICAL INFECTIOUS DISEASES, 2007, 44 (09) :1152-1158

[10] Monoclonal antibodies for prophylaxis and treatment of respiratory viral infections [J].

Boonyaratanakornkit, Jim ;

Boeckh, Michael ;

Waghmare, Alpana .

CURRENT OPINION IN INFECTIOUS DISEASES, 2022, 35 (04) :280-287

← 1 2 3 4 5 6 7 8 →