Effects of Blindness on Sleep/Wakefulness States in Mice

被引:0
|
作者
Iba, Yoshinori [1 ]
En, Shota [1 ]
Yamada, Yukika [1 ]
Koami, Mayu [1 ]
Yamamoto, Nagisa [1 ]
Sawada, Shinichi [1 ]
Yamawaki, Naono [1 ]
机构
[1] Setsunan Univ, Fac Sci & Engn, Dept Life Sci, Neyagawa, Osaka 5728508, Japan
关键词
sleep; wakefulness; light stimulation; blindness; CIRCADIAN PHOTOSENSITIVITY; RETINAL DEGENERATION; CBA/J-RD/RD; SLEEP; MELANOPSIN; PREVALENCE; LIGHT; DARK;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
To examine the effects of blindness on sleep/wakefulness states, we compared locomotor activity and delayed recovery from isoflurane anesthesia induced by hypnotics during light and dark periods in sighted CBA/N and blind CBA/J mice. Locomotor activity around the switch from the dark to light period significantly differed in both mice. Delayed recovery induced by brotizolam was attenuated in both periods in CBA/J mice. In addition, the period specificity of delayed recovery caused by suvorexant or diphenhydramine in CBA/N mice was abolished in CBA/J mice. These results suggest that blindness impairs sleep quality.
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页码:1152 / 1155
页数:4
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