共 52 条
Comparing Tear Film Viscosity between Sjogren and Non-Sjogren Dry Eye Disease
被引:2
作者:
Lai, Hung-yin
[1
]
Chen, Alexander
[2
]
Fang, Po-chiung
[3
,4
,5
]
Yu, Hun-ju
[3
,4
]
Kuo, Ming-tse
[3
,4
,5
]
机构:
[1] China Med Univ, China Med Univ Hosp, Dept Ophthalmol, Taichung 40402, Taiwan
[2] Antai Med Care Cooperat Antai Tian Sheng Mem Hosp, Dept Ophthalmol, Pingtung 92842, Taiwan
[3] Kaohsiung Chang Gung Mem Hosp, Dept Ophthalmol, Coll Med, Kaohsiung 83301, Taiwan
[4] Chang Gung Univ, Coll Med, Kaohsiung 83301, Taiwan
[5] Chang Gung Univ, Sch Med, Taoyuan City 33302, Taiwan
来源:
LIFE-BASEL
|
2023年
/
13卷
/
07期
关键词:
tear film viscosity;
reflective light particles;
tear film homeostasis;
dry eye disease;
Sjogren syndrome;
CLASSIFICATION CRITERIA;
PHYSICAL-PROPERTIES;
OCULAR SURFACE;
STABILITY;
D O I:
10.3390/life13071484
中图分类号:
Q [生物科学];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
This study aimed to compare tear film viscosity (TFV) in Sjogren and non-Sjogren dry eye diseases (DEDs). This was a cross-sectional observational study. A total of 68 DED patients were enrolled, including 32 patients with Sjogren syndrome (SS) and 36 without SS. TFV was assessed by a tear film analyzer and determined by the momentary moving speed (MMS; MMS (t) = & alpha; x t(-& beta;), t = time (s)) with its power-law fitting-derived parameters (& alpha; and & beta;). Among the four indices of TFV (MMS (0.1 s), MMS (2.0 s), & alpha;, and & beta;), the SS-DED patients had significantly lower MMS (0.1 s) (p = 2.01 x 10(-5)), & alpha; (p = 0.0375), and & beta; (p = 0.0076). The SS-DED group also had significantly higher OSDI, lower central and nasal tear meniscus height (TMH), and higher OSS. MMS (0.1 s) was significantly correlated with nasal TMH and OSS (& rho; = 0.2520, p = 0.0381 in nasal TMH; & rho; = -0.3487, p = 0.0036 in OSS). Index & beta; was not correlated with any non-TFV tests. In conclusion, MMS (0.1 s), & alpha;, and & beta; are promising TFV indices in distinguishing SS-DED from non-SS-DED patients early. Among these TFV indices, lower MMS is the best alternative clue for detecting SS-DED.
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页数:12
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