Incidental Splenic Marginal Zone Lymphoma With Extreme Macrocytosis After Hydroxyurea Use: A Case Report

被引：0

作者：

Sultan, Kinza ^{[1
]}

Kal, Sarala ^{[1
]}

Wasson, Andrew ^{[1
]}

Farmand, Farbod ^{[1
]}

机构：

[1] Arrowhead Reg Med Ctr, Internal Med, Colton, CA 92324 USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 01期

关键词：

large b-cell lymphoma; secondary malignancy; non-hodgkin lymphoma; splenic marginal zone lymphoma; hydroxyurea use; B-CELL LYMPHOMA; MYELODYSPLASTIC SYNDROMES; RITUXIMAB MONOTHERAPY; VILLOUS LYMPHOCYTES; LEUKEMOGENIC RISK; BONE-MARROW; ABERRATIONS; ACTIVATION; DISTINCT; OUTCOMES;

D O I：

10.7759/cureus.33462

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Splenic marginal zone lymphoma (SMZL) is a low-grade mature B-cell lymphoma that typically presents in the form of splenomegaly and lymphocytosis. The diagnosis is traditionally made through splenic histology, the presence of circulating villous lymphocytes, or bone marrow biopsy. Its treatment can be in the form of chemotherapy, such as rituximab, or active surveillance. This case presentation discusses a 76-year-old female with a long history of hydroxyurea use for an unknown reason presenting with atypical symptoms requiring bone marrow biopsy to diagnose SMZL. This unique case demonstrates the importance of further research and studies into atypical SMZL presentations and hydroxyurea's potential in precipitating secondary malignancies.

引用

页数：5

共 50 条

[41] NF-κB deregulation in splenic marginal zone lymphoma [J].

Spina, Valeria ;

Rossi, Davide .

SEMINARS IN CANCER BIOLOGY, 2016, 39 :61-67

[42] Splenic marginal zone B-cell lymphoma in a HIV-positive patient: a case report [J].

Arcaini, Luca ;

Sacchi, Paolo ;

Jemos, Vassili ;

Lucioni, Marco ;

Rumi, Elisa ;

Dionigi, Paolo ;

Paulli, Marco .

ANNALS OF HEMATOLOGY, 2009, 88 (04) :379-381

[43] A Case of Extranodal Marginal Zone Lymphoma of the Lung: Case Report [J].

Bektas, Sevda Sert ;

Bircan, Sema ;

Bircan, Ahmet ;

Yavuz, Gulcan ;

Gunes, Sedat ;

Sirmali, Mehmet ;

Alanoglu, Guchan .

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, 2012, 32 (02) :549-554

[44] Discordant lymphoma consisting of splenic mantle cell lymphoma and marginal zone lymphoma involving the bone marrow and peripheral blood: A case report [J].

Carulli G. ;

Marini A. ;

Ciancia E.M. ;

Bruno J. ;

Vignati S. ;

Lambelet P. ;

Cannizzo E. ;

Ottaviano V. ;

Galimberti S. ;

Caracciolo F. ;

Ferreri M.I. ;

Ciabatti E. ;

Petrini M. .

Journal of Medical Case Reports, 5 (1)

[45] A Splenic Marginal Zone Lymphoma Case Presenting with Cyanosis, Spider Angiomas, and Polycythemia [J].

Altunoglu, Esma Guldal ;

Ar, Muhlis Cem ;

Tuzuner, Nukhet ;

Saribeyoglu, Kaya .

ISTANBUL MEDICAL JOURNAL, 2015, 16 (04) :158-161

[46] Splenic marginal zone lymphoma: excellent outcomes in 64 patients treated in the rituximab era [J].

Starr, Adam G. ;

Caimi, Paolo F. ;

Fu, PingFu ;

Massoud, Mira R. ;

Meyerson, Howard ;

Hsi, Eric D. ;

Mansur, David B. ;

Cherian, Sheen ;

Cooper, Brenda W. ;

De Lima, Marcos J. G. ;

Lazarus, Hillard M. ;

Gerson, Stanton L. ;

Jagadeesh, Deepa ;

Smith, Mitchell R. ;

Dean, Robert M. ;

Pohlman, Brad L. ;

Hill, Brian T. ;

William, Basem M. .

HEMATOLOGY, 2017, 22 (07) :405-411

[47] Interference from lupus anticoagulant on von Willebrand factor measurement in splenic marginal zone lymphoma: a case report [J].

Vinholt, Pernille J. ;

Nybo, Mads .

BLOOD COAGULATION & FIBRINOLYSIS, 2015, 26 (04) :454-457

[48] Laparoscopic splenectomy for treatment of splenic marginal zone lymphoma [J].

Wu, Zhong ;

Zhou, Jin ;

Wang, Xin ;

Li, Yong-Bin ;

Niu, Ting ;

Peng, Bing .

WORLD JOURNAL OF GASTROENTEROLOGY, 2013, 19 (24) :3854-3860

[49] Laparoscopic splenectomy for treatment of splenic marginal zone lymphoma [J].

Zhong Wu ;

Jin Zhou ;

Xin Wang ;

Yong-Bin Li ;

Ting Niu ;

Bing Peng .

World Journal of Gastroenterology, 2013, (24) :3854-3860

[50] Unraveling the genetics of transformed splenic marginal zone lymphoma [J].

Grau, Marta ;

Lopez, Cristina ;

Navarro, Alba ;

Frigola, Gerard ;

Nadeu, Ferran ;

Clot, Guillem ;

Bastidas-Mora, Gabriela ;

Alcoceba, Miguel ;

Baptista, Maria Joao ;

Blanes, Margarita ;

Colomer, Dolors ;

Costa, Dolors ;

Domingo-Domenech, Eva ;

Enjuanes, Anna ;

Escoda, Lourdes ;

Forcada, Pilar ;

Gine, Eva ;

Lopez-Guerra, Monica ;

Ramon, Olga ;

Rivas-Delgado, Alfredo ;

Folch, Laura Vicente ;

Wotherspoon, Andrew ;

Climent, Fina ;

Campo, Elias ;

Lopez-Guillermo, Armando ;

Matutes, Estella ;

Bea, Silvia .

BLOOD ADVANCES, 2023, 7 (14) :3695-3709

← 1 2 3 4 5 →