Understanding CD4+ T cells in autoimmune bullous diseases

被引：5

作者：

Lee, A. Yeong ^{[1
,2
]}

Kim, Taehee ^{[1
,2
]}

Kim, Jong Hoon ^{[1
,2
]}

机构：

[1] Yonsei Univ, Gangnam Severance Hosp, Coll Med, Dept Dermatol, Seoul, South Korea

[2] Yonsei Univ, Gangnam Severance Hosp, Cutaneous Biol Res Inst, Coll Med, Seoul, South Korea

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

autoimmune bullous disease; pemphigus; bullous pemphigoid; pathogenicity; CD4 T cells; DOUBLE-BLIND TRIAL; PEMPHIGUS-VULGARIS; DESMOGLEIN; 3; INTRAVENOUS IMMUNOGLOBULIN; ACTIVE DISEASE; PIVOTAL ROLE; AUTOANTIBODIES; RITUXIMAB; AUTOANTIGEN; EPITOPES;

D O I：

10.3389/fimmu.2023.1161927

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune bullous diseases (AIBDs) are a group of life-threatening blistering diseases caused by autoantibodies that target proteins in the skin and mucosa. Autoantibodies are the most important mediator in the pathogenesis of AIBDs, and various immune mechanisms contribute to the production of these pathogenic autoantibodies. Recently, significant progress has been made in understanding how CD4(+) T cells drive autoantibody production in these diseases. Here, we review the critical role of CD4(+) T cells in the production of pathogenic autoantibodies for the initiation and perpetuation of humoral response in AIBDs. To gain an in-depth understanding of CD4(+) T-cell pathogenicity, antigen specificity, and mechanisms of immune tolerance, this review covers comprehensive mouse and human studies of pemphigus and bullous pemphigoid. Further exploration of pathogenic CD4(+) T cells will potentially provide immune targets for improved treatment of AIBDs.

引用

页数：8

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