Synthesis and Antibacterial Activity of 4-Oxo-2-thienylaminobut-2-enoic Acids

被引：17
|
作者：
Gorbunova, I. A. [1 ]
Shadrin, V. M. [2 ]
Pulina, N. A. [2 ]
Novikova, V. V. [2 ]
Dubrovina, S. S. [2 ]
Shipilovskikh, D. A. [3 ]
Shipilovskikh, S. A. [1 ,4 ]
机构：
[1] Perm State Natl Res Univ, Perm 614990, Russia
[2] Perm State Pharmaceut Acad, Minist Hlth Russia, Perm 614990, Russia
[3] Perm Natl Res Polytech Univ, Perm 614990, Russia
[4] ITMO Univ, St Petersburg 197101, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / 01期
关键词：
Gewald thiophenes; 2; 4-dioxobutanoic acids; 3-iminofuran-2-ones; antibacterial activity; antifungal activity; ANTINOCICEPTIVE ACTIVITY; ANTIMICROBIAL ACTIVITY; BIOLOGICAL EVALUATION; ANALGESIC ACTIVITY; ARYLDIKETO ACIDS; 2-AMINOTHIOPHENE; DESIGN;
D O I：
10.1134/S1070363223010024
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The hydrolysis of substituted 3-(3-cyanothiophen-2-yl)imino-3H-furan-2-ones was studied. It was found that the reaction proceeds with the opening of the furan ring and the formation of the corresponding 4-oxo-2-(3-cyanothiophen-2-yl)aminobut-2-enoic acids. The antibacterial activity of the obtained compounds against Staphylococcus aureus, Escherichia coli and Candida albicans was studied.
引用
收藏
页码：8 / 15
页数：8
相关论文
共 50 条
  • [41] Synthesis And Analgesic Activity Of 4-Aryl-2-Arylamino-4-OXO-2-Butenoic Acid Hetarylamides
    Pulina, N. A.
    Sobin, F. V.
    Kozhukhar', V. Yu.
    Makhmudov, R. R.
    Rubtsov, A. E.
    Naugol'nykh, E. A.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2014, 48 (01) : 11 - 14
  • [42] Synthesis and Antibacterial Activity of 4-Aryl-2-(1-substituted ethylidene)thiazoles
    Hassan, Alaa A.
    Ibrahim, Yusria R.
    El-Sheref, Essmat M.
    Abdel-Aziz, Mohamed
    Braese, Stefan
    Nieger, Martin
    ARCHIV DER PHARMAZIE, 2013, 346 (07) : 562 - 570
  • [43] Synthesis and antibacterial activity of 2,4,6-tri substituted s-triazines
    Srinivas, K
    Srinivas, U
    Rao, VJ
    Bhanuprakash, K
    Kishore, KH
    Murty, USN
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (04) : 1121 - 1123
  • [44] Synthesis and antimicrobial activity of substituted 5-cyano-6-oxo-2- styrylnicotinic acids
    Deyanov A.B.
    Konshin M.E.
    Chemistry of Heterocyclic Compounds, 2004, 40 (4) : 452 - 455
  • [45] Synthesis and Antinociceptive Activity ofN-Substituted 4-Aryl-4-oxo-2-[(3-thiophen-2-yl)amino]but-2-enamides
    Shipilovskikh, S. A.
    Vaganov, V. Y.
    Makhmudov, R. R.
    Rubtsov, A. E.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2020, 90 (04) : 583 - 589
  • [46] Synthesis, analgesic and antimicrobial activity of substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates
    Yu. O. Sharavyeva
    A. I. Siutkina
    S. V. Chashchina
    V. V. Novikova
    R. R. Makhmudov
    S. A. Shipilovskikh
    Russian Chemical Bulletin, 2022, 71 : 538 - 542
  • [47] Synthesis and Herbicidal Activity of 2-(2-Oxo-3-pyridyl-benzothiazol-6-yloxy)hexanoic Acids
    Huang, Yuqian
    Li, Zhanbin
    Chen, Yu
    Li, Wenqi
    Wei, Shaopeng
    Ji, Zhiqin
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2024, 72 (13) : 7457 - 7463
  • [48] Synthesis of 2-(4-methyl-1,3-thiazol-5-yl)ethyl esters of acridone carboxylic acids and evaluation of their antibacterial activity
    Markovich, Yu. D.
    Kudryavtseva, T. N.
    Bogatyrev, K. V.
    Sysoev, P. I.
    Klimova, L. G.
    Nazarov, G. V.
    RUSSIAN CHEMICAL BULLETIN, 2014, 63 (05) : 1153 - 1158
  • [49] Antibacterial activity study of 1,2,4-triazole derivatives
    Gao, Feng
    Wang, Tengfei
    Xiao, Jiaqi
    Huang, Gang
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 173 : 274 - 281
  • [50] Synthesis and antimicrobial activity of methyl esters of 2-(het)arylamino-4-oxo-Z-2-butenoic acids, their structural analogs, and conversion products
    Boteva A.A.
    Krasnykh O.P.
    Dubrovina S.S.
    Vakhrin M.I.
    Babushkina E.B.
    Odegova T.F.
    Solova I.V.
    Pharmaceutical Chemistry Journal, 2008, 42 (8) : 452 - 455
12345