PlrA (MSMEG_5223) is an essential polar growth regulator in Mycobacterium smegmatis

被引：2

作者：

Quintanilla, Samantha C. ^{[1
]}

Arejan, Neda Habibi ^{[1
]}

Patel, Parthvi ^{[1
]}

Boutte, Cara ^{[1
]}

机构：

[1] Univ Texas Arlington, Dept Biol, Arlington, TX 76019 USA

来源：

PLOS ONE | 2023年 / 18卷 / 01期

基金：

美国国家卫生研究院;

关键词：

CELL-WALL; BACILLUS-SUBTILIS; PROTEIN; DIVIVA; WAG31; PEPTIDOGLYCAN; LOCALIZATION; SELECTION; DIVISOME; CYCLE;

D O I：

10.1371/journal.pone.0280336

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mycobacteria expand their cell walls at the cell poles in a manner that is not well described at the molecular level. In this study, we identify a new polar factor, PlrA, that is involved in restricting peptidoglycan metabolism to the cell poles in Mycobacterium smegmatis. We establish that only the N-terminal membrane domain of PlrA is essential. We show that depletion of plrA pheno-copies depletion of polar growth factor Wag31, and that PlrA is involved in regulating the Wag31 polar foci.

引用

页数：14

共 4 条

[1] Mycobacterium tuberculosis Rv1302 and Mycobacterium smegmatis MSMEG___4947 have WecA function and MSMEG__4947 is required for the growth of M-smegmatis
Jin, Yue
Xin, Yi
Zhang, Wenli
Ma, Yufang
FEMS MICROBIOLOGY LETTERS, 2010, 310 (01) : 54 - 61
[2] A SIRT4-like auto ADP-ribosyltransferase is essential for the environmental growth of Mycobacterium smegmatis
Tan, Yongcong
Xu, Zhihong
Tao, Jing
Ni, Jinjing
Zhao, Wei
Lu, Jie
Yao, Yu-Feng
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2016, 48 (02) : 145 - 152
[3] ParA of Mycobacterium smegmatis co-ordinates chromosome segregation with the cell cycle and interacts with the polar growth determinant DivIVA
Ginda, Katarzyna
Bezulska, Martyna
Ziolkiewicz, Malgorzata
Dziadek, Jaroslaw
Zakrzewska-Czerwinska, Jolanta
Jakimowicz, Dagmara
MOLECULAR MICROBIOLOGY, 2013, 87 (05) : 998 - 1012
[4] Division of labor among Mycobacterium smegmatis RNase H enzymes: RNase H1 activity of RnhA or RnhC is essential for growth whereas RnhB and RnhA guard against killing by hydrogen peroxide in stationary phase
Gupta, Richa
Chatterjee, Debashree
Glickman, Michael S.
Shuman, Stewart
NUCLEIC ACIDS RESEARCH, 2017, 45 (01) : 1 - 14

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