Zn-doped Mono- and Biphasic Calcium Phosphate Materials Derived from Agriculture Waste and Their Potential Biomedical Applications: Part I

被引：4
作者：
Kalbarczyk, Marta [1 ,2 ]
Szczes, Aleksandra [1 ]
Belcarz, Anna [3 ]
Kazimierczak, Paulina [4 ]
May, Zoltan [5 ]
机构：
[1] Marie Curie Sklodowska Univ, Inst Chem Sci, Fac Chem, Dept Interfacial Phenomena, PL-20031 Lublin, Poland
[2] Lublin Univ Technol, Dept Elect Engn, PL-20618 Lublin, Poland
[3] Med Univ Lublin, Chair & Dept Biochem & Biotechnol, PL-20093 Lublin, Poland
[4] Med Univ Lublin, Independent Unit Tissue Engn & Regenerat Med, PL-20093 Lublin, Poland
[5] Inst Mat & Environm Sci, Res Ctr Nat Sci, Plasma Chem Res Grp, Magyar Tudosok krt 2, H-1117 Budapest, Hungary
来源：
MATERIALS | 2023年 / 16卷 / 05期
关键词：
hydroxyapatite; calcium phosphate; eggshells; Zn doping; antibacterial activity; cytotoxicity; ZINC-SUBSTITUTED HYDROXYAPATITE; STABILIZATION; CYTOTOXICITY; BIOACTIVITY; SCAFFOLDS; COATINGS; CERAMICS; APATITE;
D O I：
10.3390/ma16051971
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
In this study, calcium phosphate materials were obtained via a simple, eco-friendly wet synthesis method using hen eggshells as a calcium source. It was shown that Zn ions were successfully incorporated into hydroxyapatite (HA). The obtained ceramic composition depends on the zinc content. When doped with 10 mol % of Zn, in addition to HA and Zn-doped HA, DCPD (dicalcium phosphate dihydrate) appeared and its content increased with the increase in Zn concentration. All doped HA materials exhibited antimicrobial activity against S. aureus and E. coli. Nevertheless, fabricated samples significantly decreased preosteoblast (MC3T3-E1 Subclone 4) viability in vitro, exerting a cytotoxic effect which probably resulted from their high ionic reactivity.
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页数：15
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