Immunotherapy for deficient mismatch repair (dMMR) pancreatic ductal adenocarcinoma

被引:2
作者
Ebia, Matthew I. [1 ]
Hitchins, Megan P. [2 ]
Hendifar, Andrew E. [1 ,3 ,4 ]
机构
[1] Cedars Sinai Med Ctr, Dept Med, Div Hematol & Oncol, Los Angeles, CA USA
[2] Cedars Sinai Med Ctr, Dept Biomed Sci, Los Angeles, CA USA
[3] Cedars Sinai Samuel Oschin Comprehens Canc Inst, Los Angeles, CA USA
[4] Cedars Sinai Med Ctr, Dept Med, Div Hematol & Oncol, 8700 Beverly Blvd,Suite 1042AC, Los Angeles, CA 90048 USA
关键词
Pancreatic ductal adenocarcinoma (PDAC); DNA deficient mismatch repair (DNA dMMR); microsatellite instability (MSI); Lynch syndrome; immunotherapy; CANCER;
D O I
10.21037/jgo-23-12
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:1175 / 1177
页数:3
相关论文
共 50 条
  • [41] Identification and Validation of Immune Molecular Subtypes in Pancreatic Ductal Adenocarcinoma: Implications for Prognosis and Immunotherapy
    Li, Ruiyu
    He, Yangzhige
    Zhang, Hui
    Wang, Jing
    Liu, Xiaoding
    Liu, Hangqi
    Wu, Huanwen
    Liang, Zhiyong
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [42] Investigating somatic variants and pathways in mismatch repair-deficient (dMMR) colorectal carcinoma in South Africa
    Aldera, Alessandro Pietro
    van der Westhuizen, Jana
    Tsai, Wan-Jung
    Krause, May J.
    Yildiz, Safiye
    Pillay, Komala
    Boutall, Adam
    Ramesar, Raj
    JOURNAL OF CLINICAL PATHOLOGY, 2024,
  • [43] The role of DNA mismatch repair in immunotherapy of human cancer
    He, Yuchen
    Zhang, Luyuan
    Zhou, Ruoyu
    Wang, Yumin
    Chen, Hao
    INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2022, 18 (07): : 2821 - 2832
  • [44] Pancreatic cancer precursor lesions - Can immunotherapy prevent progression into pancreatic ductal adenocarcinoma?
    Enzler, Thomas
    Frankel, Timothy L.
    CANCER LETTERS, 2025, 619
  • [45] Genomic Features and Classification of Homologous Recombination Deficient Pancreatic Ductal Adenocarcinoma
    Golan, Talia
    O'Kane, Grainne M.
    Denroche, Robert E.
    Raitses-Gurevich, Maria
    Grant, Robert C.
    Holter, Spring
    Wang, Yifan
    Zhang, Amy
    Jang, Gun Ho
    Stossel, Chani
    Atias, Dikla
    Halperin, Sharon
    Berger, Raanan
    Glick, Yulia
    Park, J. Patrick
    Cuggia, Adeline
    Williamson, Laura
    Wong, Hui-Li
    Schaeffer, David F.
    Renouf, Daniel J.
    Borgida, Ayelet
    Dodd, Anna
    Wilson, Julie M.
    Fischer, Sandra E.
    Notta, Faiyaz
    Knox, Jennifer J.
    Zogopoulos, George
    Gallinger, Steven
    GASTROENTEROLOGY, 2021, 160 (06) : 2119 - +
  • [46] Role of targeted immunotherapy for pancreatic ductal adenocarcinoma (PDAC) treatment: An overview
    Panchal, Kanan
    Sahoo, Rakesh Kumar
    Gupta, Umesh
    Chaurasiya, Akash
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 95
  • [47] ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy
    Wang, Mingchao
    Ran, Xiaojuan
    Leung, Wendy
    Kawale, Ajinkya
    Saxena, Sneha
    Ouyang, Jian
    Patel, Parasvi S.
    Dong, Yuting
    Yin, Tao
    Shu, Jian
    Manguso, Robert T.
    Lan, Li
    Wang, Xiao-Fan
    Lawrence, Michael S.
    Zou, Lee
    GENES & DEVELOPMENT, 2023, 37 (19-20) : 929 - 943
  • [48] Where Do We Stand with Immunotherapy for Advanced Pancreatic Ductal Adenocarcinoma: A Synopsis of Clinical Outcomes
    Akhuba, Liia
    Tigai, Zhanna
    Shek, Dmitrii
    BIOMEDICINES, 2022, 10 (12)
  • [49] Targeting Neoantigens in Pancreatic Ductal Adenocarcinoma
    Singh, Gurkaranjot
    Kutcher, Drew
    Lally, Rajeshwar
    Rai, Vikrant
    CANCERS, 2024, 16 (11)
  • [50] Oral mycobiota and pancreatic ductal adenocarcinoma
    Wei, Ailin
    Zhao, Huiling
    Cong, Xue
    Wang, Linyao
    Chen, Yiyang
    Gou, Juxiang
    Hu, Ziyi
    Hu, Xiuying
    Tian, Yali
    Li, Ka
    Deng, Yufeng
    Zuo, Haojiang
    Fu, Mei Rosemary
    BMC CANCER, 2022, 22 (01)