Translational veterinary epilepsy: A win-win situation for human and veterinary neurology

被引：13

作者：

Charalambous, Marios ^{[1
]}

Fischer, Andrea ^{[2
]}

Potschka, Heidrun ^{[3
]}

Walker, Matthew C. ^{[4
]}

Raedt, Robrecht ^{[5
]}

Vonck, Kristl ^{[5
]}

Boon, Paul ^{[5
]}

Lohi, Hannes ^{[6
,7
]}

Loescher, Wolfgang ^{[8
]}

Worrell, Gregory ^{[9
]}

Leeb, Tosso ^{[10
]}

McEvoy, Andrew ^{[4
]}

Striano, Pasquale ^{[11
,12
]}

Kluger, Gerhard ^{[13
,14
]}

Galanopoulou, Aristea S. ^{[15
]}

Volk, Holger A. ^{[1
]}

Bhatti, Sofie F. M. ^{[16
]}

机构：

[1] Univ Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, Germany

[2] Ludwig Maximilians Univ Munchen, Ctr Clin Vet Med, D-80539 Munich, Germany

[3] Ludwig Maximilians Univ Munchen, Inst Pharmacol Toxicol & Pharm, D-80539 Munich, Germany

[4] UCL, Inst Neurol, London WC1N 3JD, England

[5] Univ Ghent, Dept Neurol, 4brain, B-9000 Ghent, Belgium

[6] Univ Helsinki, Dept Vet Biosci, Dept Med & Clin Genet, Helsinki 00014, Finland

[7] Univ Helsinki, Folkhalsan Res Ctr, Helsinki 00014, Finland

[8] Univ Vet Med Hannover, Dept Pharmacol Toxicol & Pharm, D-30559 Hannover, Germany

[9] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA

[10] Univ Ghent, Inst Genet, Small Anim Dept, B-9820 Merelbeke, Belgium

[11] IRCCS G Gaslini, I-16147 Genoa, Italy

[12] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Genoa, Italy

[13] PMU Salzburg, Res Inst Rehabil Transit Palliat, A-5020 Salzburg, Austria

[14] Schoen Clin Vogtareuth, Epilepsy Ctr Children & Adolescents, Clin Neuropediat & Neurorehabil, D-83569 Vogtareuth, Germany

[15] Albert Einstein Coll Med, Montefiore Med Ctr, Saul R Korey Dept Neurol,Isabelle Rapin Div Child, Dominick P Purpura Dept Neurosci, Bronx, NY 10461 USA

[16] Univ Ghent, Small Anim Dept, Fac Vet Med, B-9820 Merelbeke, Belgium

来源：

VETERINARY JOURNAL | 2023年 / 293卷

关键词：

Dog; Human; Nervous system; Seizures; Therapy; VAGUS NERVE-STIMULATION; QUALITY-OF-LIFE; INDUCED UP-REGULATION; CANINE STATUS EPILEPTICUS; DRUG-RESISTANT EPILEPSY; BLOOD-BRAIN-BARRIER; IDIOPATHIC EPILEPSY; P-GLYCOPROTEIN; ANTIEPILEPTIC DRUGS; TASK-FORCE;

D O I：

10.1016/j.tvjl.2023.105956

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Epilepsy is a challenging multifactorial disorder with a complex genetic background. Our current understanding of the pathophysiology and treatment of epilepsy has substantially increased due to animal model studies, including canine studies, but additional basic and clinical research is required. Drug-resistant epilepsy is an important problem in both dogs and humans, since seizure freedom is not achieved with the available antiseizure medications. The evaluation and exploration of pharmacological and particularly non-pharmacological thera-peutic options need to remain a priority in epilepsy research. Combined efforts and sharing knowledge and expertise between human medical and veterinary neurologists are important for improving the treatment out-comes or even curing epilepsy in dogs. Such interactions could offer an exciting approach to translate the knowledge gained from people and rodents to dogs and vice versa. In this article, a panel of experts discusses the similarities and knowledge gaps in human and animal epileptology, with the aim of establishing a common framework and the basis for future translational epilepsy research.

引用

页数：12

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