Web-Based Nomograms for Overall Survival and Cancer-Specific Survival of Bladder Cancer Patients with Bone Metastasis: A Retrospective Cohort Study from SEER Database

被引:2
|
作者
Yang, Sheng [1 ,2 ]
Zhou, Hongmin [3 ]
Feng, Chaobo [1 ,2 ]
Xu, Ningze [4 ]
Fan, Yunshan [1 ,2 ]
Zhou, Zhi [1 ,2 ]
Xu, Yunfei [3 ]
Fan, Guoxin [5 ,6 ,7 ]
Liao, Xiang [5 ]
He, Shisheng [1 ,2 ]
机构
[1] Tongji Univ, Shanghai Peoples Hosp 10, Dept Orthoped, Sch Med, Shanghai 200072, Peoples R China
[2] Tongji Univ, Spinal Pain Res Inst, Sch Med, Shanghai 200072, Peoples R China
[3] Tongji Univ, Shanghai Peoples Hosp 10, Dept Urol, Sch Med, Shanghai 200072, Peoples R China
[4] Tongji Univ, Shanghai Peoples Hosp 10, Dept Obstet & Gynecol, Sch Med, Shanghai 200072, Peoples R China
[5] Huazhong Univ Sci & Technol, Union Shenzhen Hosp, Natl Key Clin Pain Med China, Shenzhen 518052, Peoples R China
[6] Shenzhen Univ, Sch Biomed Engn, Guangdong Key Lab Biomed Measurements & Ultrasound, Hlth Sci Ctr, Shenzhen 518060, Peoples R China
[7] Sun Yat sen Univ, Affiliated Hosp 3, Dept Spine Surg, Guangzhou 510630, Peoples R China
基金
中国国家自然科学基金;
关键词
SEER; prognostic factor; bladder cancer; bone metastasis; survival prediction; nomogram; PROGNOSTIC VALUE; PATTERN; CELLS;
D O I
10.3390/jcm12020726
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Our study aimed to explore the prognostic factors of bladder cancer with bone metastasis (BCBM) and develop prediction models to predict the overall survival (OS) and cancer-specific survival (CSS) of BCBM patients. Methods: A total of 1438 patients with BCBM were obtained from the SEER database. Patients from 2010 to 2016 were randomly divided into training and validation datasets (7:3), while patients from 2017 were divided for external testing. Nomograms were established using prognostic factors identified through Cox regression analyses and validated internally and externally. The concordance index (C-index), calibration plots, and time-dependent receiver operating characteristic (ROC) curves were used to evaluate the discrimination and calibration of nomogram models, while decision curve analyses (DCA) and Kaplan-Meier (KM) curves were used to estimate the clinical applicability. Results: Marital status, tumor metastasis (brain, liver, and lung), primary site surgery, and chemotherapy were indicated as independent prognostic factors for OS and CSS. Calibration plots and the overall C-index showed a novel agreement between the observed and predicted outcomes. Nomograms revealed significant advantages in OS and CSS predictions. AUCs for internal and external validation were listed as follows: for OS, 3-month AUCs were 0.853 and 0.849; 6-month AUCs were 0.873 and 0.832; 12-month AUCs were 0.825 and 0.805; for CSS, 3-month AUCs were 0.849 and 0.847; 6-month AUCs were 0.870 and 0.824; 12-month AUCs were 0.815 and 0.797, respectively. DCA curves demonstrated good clinical benefit, and KM curves showed distinct stratification performance. Conclusion: The nomograms as web-based tools were proved to be accurate, efficient, and clinically beneficial, which might help in patient management and clinical decision-making for BCBM patients.
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页数:16
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