Assembled Morphology of Copper-Thiourea Coordination-Mediated Metallo-Supramolecular Polymers

被引:2
作者
Qiu, Xiaoyang [1 ]
Chen, Senbin [1 ]
Zhu, Jintao [1 ]
机构
[1] Huazhong Univ Sci & Technol HUST, Hubei Engn Res Ctr Biomat & Med Protect Mat, Sch Chem & Chem Engn, Wuhan 430074, Peoples R China
基金
中国国家自然科学基金;
关键词
coordination interaction; metallo-supramolecular polymers; rod-like nano-objects; self-assembly; thiourea motif; COMPLEXES;
D O I
10.1002/marc.202200918
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Metallo-supramolecular polymers represent a powerful platform to construct self-assembled morphologies. Copper-thiourea (Cu-TU) coordination interactions, though have been extensively studied in small molecular system, the role of TU motifs in synthetic polymers using metal-ligand coordination to afford supramolecular aggregation and their morphology are often overlooked. Herein, an amphiphilic random copolymer, poly(oligo(ethylene glycol) ethyl acrylate-r-acylthiourea) (P(OEGEA-r-ATU)), bearing pendant TU motifs behaving as the ligand to coordinate Cu, a design characterized by core-coordinated metallo-supramolecular polymer is rationally synthesized. Indeed, rod-like nano-objects are successfully generated via the self-assembly and coordination interaction between P(OEGEA-r-ATU) and Cu. The spatial distribution of TU moieties in polymer chain, along with their Cu chelating capability, featuring the interchain coordination interaction, is tightly related to metallo-supramolecular polymer organization. The specific Cu-TU coordination interactions enable the prompted robustness and stability of soft P(OEGEA-r-ATU), induce the polymer chain configuration, which eventually furnish efficient fabrication of rod-like nano-objects via straightforward nanoprecipitation procedure. These structural motifs of copper-coordinated, rod-like nano-objects from such metallo-supramolecular polymers endow the potential therapeutic properties, such as anti-inflammatory and antitumor effects.
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页数:7
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