Recommendations for measuring and standardizing light for laboratory mammals to improve welfare and reproducibility in animal research

被引:16
作者
Lucas, Robert J. [1 ]
Allen, Annette E. [1 ]
Brainard, George C. [2 ]
Brown, Timothy M. [1 ]
Dauchy, Robert T. [3 ]
Didikoglu, Altug [4 ]
Do, Michael Tri H. [5 ,6 ,7 ]
Gaskill, Brianna N. [8 ]
Hattar, Samer [9 ]
Hawkins, Penny [10 ]
Hut, Roelof A. [11 ]
McDowell, Richard J. [1 ]
Nelson, Randy J. [12 ]
Prins, Jan-Bas [13 ,14 ]
Schmidt, Tiffany M. [15 ]
Takahashi, Joseph S. [16 ,17 ]
Verma, Vandana [18 ]
Voikar, Vootele [19 ,20 ]
Wells, Sara [21 ]
Peirson, Stuart N. [22 ]
机构
[1] Univ Manchester, Fac Biol Med & Hlth, Ctr Biol Timing, Sch Biol Sci, Manchester, England
[2] Thomas Jefferson Univ, Dept Neurol, Philadelphia, PA USA
[3] Tulane Univ, Sch Med, Dept Struct & Cellular Biol, Tulane, LA USA
[4] Izmir Inst Technol, Dept Neurosci, Urla, Izmir, Turkiye
[5] FM Kirby Neurobiol Ctr, Boston, MA USA
[6] Boston Childrens Hosp, Dept Neurol, Boston, MA USA
[7] Harvard Med Sch, Ctr Life Sci, Boston, MA USA
[8] Novartis Inst Biomed Res, Cambridge, MA USA
[9] NIMH, Sect Light & Circadian Rhythms, John Edward Porter Neurosci Res Ctr, Bethesda, MD USA
[10] RSPCA, Horsham, W Sussex, England
[11] Univ Groningen, Groningen Inst Evolutionary Life Sci, Chronobiol Unit, Groningen, Netherlands
[12] West Virginia Univ, Rockefeller Neurosci Inst, Dept Neurosci, Morgantown, WV USA
[13] Francis Crick Inst, London, England
[14] Leiden Univ, Med Ctr, Leiden, Netherlands
[15] Northwestern Univ, Dept Neurobiol, Evanston, IL USA
[16] Univ Texas Southwestern Med Ctr, Peter ODonnell Jr Brain Inst, Dept Neurosci, Dallas, TX USA
[17] Univ Texas Southwestern Med Ctr, Howard Hughes Med Inst, Dallas, TX USA
[18] Ames Res Ctr, Space Biosci Div, Moffett Field, Moffett Field, CA USA
[19] Univ Helsinki, Lab Anim Ctr, Helsinki, Finland
[20] Univ Helsinki, Neurosci Ctr, HiLIFE, Helsinki, Finland
[21] Mary Lyon Ctr, MRC Harwell, Harwell Campus, Didcot, Oxon, England
[22] Univ Oxford, Sleep & Circadian Neurosci Inst SCNi, Kavli Inst Nanosci Discovery, Nuffield Dept Clin Neurosci, Oxford, England
关键词
RETINAL GANGLION-CELLS; SPECTRAL SENSITIVITY; COLOR-VISION; CIRCADIAN METABOLISM; ULTRAVIOLET-LIGHT; MELANOPSIN; CONE; PHOTORECEPTORS; ROD; ENTRAINMENT;
D O I
10.1371/journal.pbio.3002535
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Light enables vision and exerts widespread effects on physiology and behavior, including regulating circadian rhythms, sleep, hormone synthesis, affective state, and cognitive processes. Appropriate lighting in animal facilities may support welfare and ensure that animals enter experiments in an appropriate physiological and behavioral state. Furthermore, proper consideration of light during experimentation is important both when it is explicitly employed as an independent variable and as a general feature of the environment. This Consensus View discusses metrics to use for the quantification of light appropriate for nonhuman mammals and their application to improve animal welfare and the quality of animal research. It provides methods for measuring these metrics, practical guidance for their implementation in husbandry and experimentation, and quantitative guidance on appropriate light exposure for laboratory mammals. The guidance provided has the potential to improve data quality and contribute to reduction and refinement, helping to ensure more ethical animal use. Lighting conditions for laboratory mammals is currently set according to the sensitivity of human vision. This Consensus View defines alternative 'animal-centric' metrics and provides guidance for their application to standardize experimental conditions, improve animal welfare and the quality of animal research.
引用
收藏
页数:24
相关论文
共 124 条
[1]   Circadian Mechanisms in Medicine [J].
Allada, Ravi ;
Bass, Joseph .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (06) :550-561
[2]   Rods-cones and melanopsin detect light and dark to modulate sleep independent of image formation [J].
Altimus, C. M. ;
Guler, A. D. ;
Villa, K. L. ;
McNeill, D. S. ;
LeGates, T. A. ;
Hattar, S. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (50) :19998-20003
[3]   Rod photoreceptors drive circadian photoentrainment across a wide range of light intensities [J].
Altimus, Cara M. ;
Gueler, Ali D. ;
Alam, Nazia M. ;
Arman, A. Cyrus ;
Prusky, Glen T. ;
Sampath, Alapakkam P. ;
Hattar, Samer .
NATURE NEUROSCIENCE, 2010, 13 (09) :1107-U102
[4]  
Altshuler DL, 2001, EVOL ECOL RES, V3, P767
[5]   An Expanding Role for Nonvisual Opsins in Extraocular Light Sensing Physiology [J].
Andrabi, Mutahar ;
Upton, Brian A. ;
Lang, Richard A. ;
Vemaraju, Shruti .
ANNUAL REVIEW OF VISION SCIENCE, 2023, 9 :245-267
[6]   Female European green lizards (Lacerta viridis) prefer males with high ultraviolet throat reflectance [J].
Bajer, Katalin ;
Molnar, Orsolya ;
Torok, Janos ;
Herczeg, Gabor .
BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY, 2010, 64 (12) :2007-2014
[7]   Bright daytime light enhances circadian amplitude in a diurnal mammal [J].
Bano-Otalora, Beatriz ;
Martial, Franck ;
Harding, Court ;
Bechtold, David A. ;
Allen, Annette E. ;
Brown, Timothy M. ;
Belle, Mino D. C. ;
Lucas, Robert J. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (22)
[8]   Evaluation of Ambient Sound, Vibration, and Light in Rodent Housing Rooms [J].
Barabas, Amanda J. ;
Darbyshire, Amanda K. ;
Schlegel, Sylvia L. ;
Gaskill, Brianna N. .
JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE, 2022, 61 (06) :660-671
[9]   Light at Night Alters Daily Patterns of Cortisol and Clock Proteins in Female Siberian Hamsters [J].
Bedrosian, T. A. ;
Galan, A. ;
Vaughn, C. A. ;
Weil, Z. M. ;
Nelson, R. J. .
JOURNAL OF NEUROENDOCRINOLOGY, 2013, 25 (06) :590-596
[10]   Endocrine Effects of Circadian Disruption [J].
Bedrosian, Tracy A. ;
Fonken, Laura K. ;
Nelson, Randy J. .
ANNUAL REVIEW OF PHYSIOLOGY, VOL 78, 2016, 78 :109-131