Lipid Metabolism as a Potential Target of Liver Cancer

被引：3
|
作者：
Wu, Kangze [1 ]
Lin, Feizhuan [1 ]
机构：
[1] Shaoxing Peoples Hosp, Dept Hepatobiliary Surg, Shaoxing, Peoples R China
来源：
JOURNAL OF HEPATOCELLULAR CARCINOMA | 2024年 / 11卷
关键词：
cholesterol; fatty acid; hepatocellular carcinoma; lipid uptake; lipid catabolism; lipid synthesis; ATP CITRATE LYASE; ELEMENT-BINDING PROTEIN; FATTY-ACID-METABOLISM; COA SYNTHETASE 2; HEPATOCELLULAR-CARCINOMA; THERAPEUTIC TARGET; CELL-GROWTH; POOR-PROGNOSIS; BETA-OXIDATION; GASTRIC-CANCER;
D O I：
10.2147/JHC.S450423
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hepatocellular carcinoma (HCC) stands as a severe malignant tumor with a profound impact on overall health, often accompanied by an unfavorable prognosis. Despite some advancements in the diagnosis and treatment of this disease, improving the prognosis of HCC remains a formidable challenge. It is noteworthy that lipid metabolism plays a pivotal role in the onset, development, and progression of tumor cells. Existing research indicates the potential application of targeting lipid metabolism in the treatment of HCC. This review aims to thoroughly explore the alterations in lipid metabolism in HCC, offering a detailed account of the potential advantages associated with innovative therapeutic strategies targeting lipid metabolism. Targeting lipid metabolism holds promise for potentially enhancing the prognosis of HCC.
引用
收藏
页码：327 / 346
页数：20
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