Incidence and predictors of metabolic syndrome onset in individuals with bipolar disorders: A longitudinal study from the FACE-BD cohort

被引：4

作者：

Godin, O. ^{[1
,2
]}

Olie, E. ^{[1
,3
]}

Fond, G. ^{[1
,4
]}

Aouizerate, B. ^{[1
,5
]}

Aubin, V. ^{[1
,6
]}

Bellivier, F. ^{[1
,7
,8
]}

Belzeaux, R. ^{[1
,9
,10
]}

Courtet, P. ^{[1
,3
]}

Dubertret, C. ^{[1
,11
]}

Haffen, E. ^{[1
,12
]}

Lefrere, A. ^{[1
,13
,14
]}

Llorca, P. M. ^{[1
,15
]}

Polosan, M. ^{[1
,16
]}

Roux, P. ^{[1
,17
,18
]}

Samalin, L. ^{[1
,15
]}

Schwan, R. ^{[1
,19
]}

Leboyer, M. ^{[1
,2
,20
]}

Etain, B. ^{[1
,7
,8
]}

机构：

[1] Fdn FondaMental, Creteil, France

[2] Univ Paris Est Creteil, INSERM U955, Translat Neuropsychiat Lab, IMRB, Creteil, France

[3] Univ Montpellier, Dept Emergency Psychiat & Acute Care, INSERM, IGF,CHU Montpellier,CNRS, Montpellier, France

[4] Aix Marseille Univ, Acad Dept Psychiat, Resistant Depress Expert Ctr, CHU La Conception,AP HM,FondaMental Fdn, Marseille, France

[5] Univ Bordeaux, Lab NutriNeuro UMR INRAE 1286, Ctr Hosp Charles Perrens, Pole Psychiat Gen & Univ, Bordeaux, France

[6] Ctr Hosp Princesse Grace, Pole Psychiat, Monaco, Monaco

[7] Univ Paris Cite, INSERM UMR S 1144, Optimisat Therapeut Neuropsychopharmacol OTeN, Paris, France

[8] DMU Neurosci, AP HP, Dept Psychiat & Med Addictol, Grp Hosp Univ AP HP Nord,Hop Fernand Widal, Paris, France

[9] Univ Montpellier, Montpellier, France

[10] CHU Montpellier, Dept Psychiat, Montpellier, France

[11] Hop Louis Mourier, Dept Psychiat, AHPH, Colombes, France

[12] Univ Franche Comte, INSERM, UR LINC 481, CHU Besancon,Serv Psychiat Adulte,CIC 1431, Besancon, France

[13] Assistance Publ Hop Marseille, Pole Psychiat, Marseille, France

[14] Aix Marseille Univ, CNRS, INT UMR7289, Marseille, France

[15] Univ Clermont Auvergne, CNRS, Dept Psychiat,UMR 6602, CHU Clermont Ferrand,Clermont Auvergne INP,Inst P, Clermont Ferrand, France

[16] Univ Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes,Grenoble Inst Neurosci, Grenoble, France

[17] Ctr Hosp Versailles, Serv Univ Psychiat Adulte & Addictol, Le Chesnay, France

[18] Univ Paris Saclay, Univ Versailles St Quentin En Yvelines, INSERM, DisAP DevPsy CESP,UMR1018, Villejuif, France

[19] Univ Lorraine, Ctr Psychotherap Nancy, Inserm, U1254, Nancy, France

[20] Federat Hosp Univ Medecine Precis Psychiat FHU AD, Dept Med Univ Psychiat & Addictol DMUIMPACT, Hop Univ Henri Mondor, AP HP, Creteil, France

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 2024年 / 149卷 / 03期

关键词：

bipolar disorders; diabetes; incidence; longitudinal; metabolic syndrome; CARDIOVASCULAR-DISEASE; WEIGHT-GAIN; ALL-CAUSE; PREVALENCE; MORTALITY; SCHIZOPHRENIA; RISK; SCALE; INDEX; ANTIPSYCHOTICS;

D O I：

10.1111/acps.13655

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

IntroductionMetabolic syndrome (MetS) is a cluster of components including abdominal obesity, hyperglycemia, hypertension, and dyslipidemia. MetS is highly prevalent in individuals with bipolar disorders (BD) with an estimated global rate of 32.6%. Longitudinal data on incident MetS in BD are scarce and based on small sample size. The objectives of this study were to estimate the incidence of MetS in a large longitudinal cohort of 1521 individuals with BD and to identify clinical and biological predictors of incident MetS.Methods: Participants were recruited from the FondaMental Advanced Center of Expertise for Bipolar Disorder (FACE-BD) cohort and followed-up for 3 years. MetS was defined according to the International Diabetes Federation criteria. Individuals without MetS at baseline but with MetS during follow-up were considered as having incident MetS. A logistic regression model was performed to estimate the adjusted odds ratio and its corresponding 95% confidence interval (CI) for an association between each factor and incident MetS during follow-up. We applied inverse probability-of-censoring weighting method to minimize selection bias due to loss during follow-up.Results: Among individuals without MetS at baseline (n = 1521), 19.3% developed MetS during follow-up. Multivariable analyses showed that incident MetS during follow-up was significantly associated with male sex (OR = 2.2, 95% CI = 1.7-3.0, p < 0.0001), older age (OR = 2.14, 95% CI = 1.40-3.25, p = 0.0004), presence of a mood recurrence during follow-up (OR = 1.91, 95% CI = 1.22-3.00, p = 0.0049), prolonged exposure to second-generation antipsychotics (OR = 1.56, 95% CI = 0.99, 2.45, p = 0.0534), smoking status at baseline (OR = 1.30, 95% CI = 1.00-1.68), lifetime alcohol use disorders (OR = 1.33, 95% CI = 0.98-1.79), and baseline sleep disturbances (OR = 1.04, 95% CI = 1.00-1.08), independently of the associations observed for baseline MetS components.Conclusion: We observed a high incidence of MetS during a 3 years follow-up (19.3%) in individuals with BD. Identification of predictive factors should help the development of early interventions to prevent or treat early MetS.

引用

页码：207 / 218

页数：12

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