Targeting Venetoclax Resistance in TP53-Mutated Acute Myeloid Leukemia

被引：0
|
作者：
Vanttinen, Ida [1 ,2 ]
Ruokoranta, Tanja [1 ]
Saad, Joseph J. [1 ,2 ]
Kytola, Sari [3 ]
Hellesoy, Monica [4 ]
Gullaksen, Stein-Erik [4 ]
Ettala, Pia-Sofia [5 ]
Pyorala, Marja [6 ]
Rimpilainen, Johanna [7 ]
Siitonen, Timo [8 ]
Wennerberg, Krister [9 ]
Gjertsen, Bjorn T. [4 ,10 ]
Heckman, Caroline A. [1 ,2 ]
Kontro, Mika [1 ,2 ,3 ,11 ]
Kuusanmaki, Heikki [1 ,2 ,9 ,11 ]
机构：
[1] Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki, Finland
[2] ICAN Digital Precis Canc Med Flagship, Helsinki, Finland
[3] Helsinki Univ Hosp, Dept Hematol, Comprehens Canc Ctr, Helsinki, Finland
[4] Helse Bergen, Hematol Sect, Dept Med, Bergen, Norway
[5] Turku Univ Hosp, Dept Clin Hematol, Turku, Finland
[6] Kuopio Univ Hosp, Dept Med, Kuopio, Finland
[7] Tampere Univ Hosp, Dept Internal Med, Tampere, Finland
[8] Oulu Univ Hosp, Canc Ctr, Hematol, Oulu, Finland
[9] Univ Copenhagen, Biotech Res & Innovat Ctr BRIC, Copenhagen, Denmark
[10] Univ Bergen, Dept Clin Sci, Ctr Canc Biomarkers CCBIO, Bergen, Norway
[11] Fdn Finnish Canc Inst, Helsinki, Finland
来源：
BLOOD | 2023年 / 142卷
关键词：
D O I：
10.1182/blood-2023-189340
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页数：4
相关论文
共 50 条
  • [31] TP53-Mutated Myelodysplastic Syndrome and Acute Myeloid Leukemia: Biology, Current Therapy, and Future Directions
    Daver, Naval G.
    Maiti, Abhishek
    Kadia, Tapan M.
    Vyas, Paresh
    Majeti, Ravindra
    Wei, Andrew H.
    Garcia-Manero, Guillermo
    Craddock, Charles
    Sallman, David A.
    Kantarjian, Hagop M.
    CANCER DISCOVERY, 2022, 12 (11) : 2516 - 2529
  • [32] TP53-mutated acute myeloid leukemia and myelodysplastic syndrome: biology, treatment challenges, and upcoming approaches
    Mariana Pinto Pereira
    Elizabeth Herrity
    Dennis D.H Kim
    Annals of Hematology, 2024, 103 : 1049 - 1067
  • [33] Genomic landscape of TP53-mutated myeloid malignancies
    Abel, Haley J.
    Oetjen, Karolyn A.
    Miller, Christopher A.
    Ramakrishnan, Sai M.
    Day, Ryan B.
    Helton, Nichole M.
    Fronick, Catrina C.
    Fulton, Robert S.
    Heath, Sharon E.
    Tarnawsky, Stefan P.
    Srivatsan, Sridhar Nonavinkere
    Duncavage, Eric J.
    Schroeder, Molly C.
    Payton, Jacqueline E.
    Spencer, David H.
    Walter, Matthew J.
    Westervelt, Peter
    Dipersio, John F.
    Ley, Timothy J.
    Link, Daniel C.
    BLOOD ADVANCES, 2023, 7 (16) : 4586 - 4598
  • [34] Challenges and emerging therapeutic strategies for TP53-mutated acute myeloid leukemia: still disappointing findings?
    Molica, Matteo
    EXPERT REVIEW OF HEMATOLOGY, 2025, 18 (01) : 1 - 4
  • [35] TP53-mutated Acute Myeloid Leukemia with Myelodysplasia-Related Changes and TherapyRelated Acute Myeloid Leukemia Have Comparable TP53 Mutational Signature and Clinical Features
    Tashakori, Mehrnoosh
    Tapan, Kadia
    Loghavi, Sanam
    Tang, Zhenya
    Routbort, Mark
    Ravandi-Kashani, Farhad
    Khoury, Joseph
    MODERN PATHOLOGY, 2022, 35 (SUPPL 2) : 1027 - 1028
  • [36] Impact of induction intensity and transplantation on outcomes of patients with complex karyotype and TP53-mutated acute myeloid leukemia
    Jamy, Omer
    Diebold, Kendall
    Davis, Kenneth
    Bachiashvili, Kimo
    Rangaraju, Sravanti
    Vachhani, Pankit
    Godby, Kelly N.
    Salzman, Donna
    Bhatia, Ravi
    BONE MARROW TRANSPLANTATION, 2023, 58 (07) : 823 - 825
  • [37] Impact of induction intensity and transplantation on outcomes of patients with complex karyotype and TP53-mutated acute myeloid leukemia
    Omer Jamy
    Kendall Diebold
    Kenneth Davis
    Kimo Bachiashvili
    Sravanti Rangaraju
    Pankit Vachhani
    Kelly N. Godby
    Donna Salzman
    Ravi Bhatia
    Bone Marrow Transplantation, 2023, 58 : 823 - 825
  • [38] Decitabine salvage for TP53-mutated, relapsed/refractory acute myeloid leukemia after cytotoxic induction therapy
    Ferraro, Francesca
    Gruszczynska, Agata
    Ruzinova, Marianna B.
    Miller, Christopher A.
    Percival, Mary Elizabeth
    Uy, Geoffrey L.
    Pusic, Iskra
    Jacoby, Meagan A.
    Christopher, Mathew J.
    Kim, Miriam Y.
    Westervelt, Peter
    Cashen, Amanda F.
    Schroeder, Mark A.
    DiPersio, John F.
    Abboud, Camille N.
    Wartman, Lukas D.
    Gao, Feng
    Link, Daniel C.
    Ley, Timothy J.
    Welch, John S.
    HAEMATOLOGICA, 2022, 107 (07) : 1709 - 1713
  • [39] The XPO7-NPAT axis represents key vulnerabilities in TP53-mutated acute myeloid leukemia
    Semba, Yuichiro
    Yamauchi, Takuji
    Bauer, Daniel E.
    Ogawa, Seishi
    Akashi, Koichi
    Maeda, Takahiro
    CANCER SCIENCE, 2025, 116 : 139 - 139
  • [40] TP53-mutated Acute Myeloid Leukemia with Myelodysplasia-Related Changes and Therapy-Related Acute Myeloid Leukemia Have Comparable TP53 Mutational Signature and Clinical Features
    Tashakori, Mehrnoosh
    Tapan, Kadia
    Loghavi, Sanam
    Tang, Zhenya
    Routbort, Mark
    Ravandi-Kashani, Farhad
    Khoury, Joseph
    LABORATORY INVESTIGATION, 2022, 102 (SUPPL 1) : 1027 - 1028
12345