Associations between Catechol-O-methyltransferase (COMT) polymorphisms and cognitive impairments, psychiatric symptoms and tardive dyskinesia in schizophrenia

被引:1
作者
Chi, Jinghui [1 ]
Ma, Yanyan [1 ]
Shi, Menglei [3 ]
Lu, Chenghao [1 ]
Jiang, Qiaona [1 ]
Li, Yanzhe [2 ]
Zhang, Xiaofei [1 ]
Shi, Xiaomei [1 ]
Wang, Lili [1 ,4 ]
Li, Shen [2 ,5 ]
机构
[1] Tianjin Med Univ, Tianjin Anding Hosp, Dept Psychiat, Mental Hlth Ctr, Tianjin 300222, Peoples R China
[2] Tianjin Med Univ, Tianjin Anding Hosp, Inst Mental Hlth, Lab Biol Psychiat,Mental Hlth Ctr, Tianjin 300222, Peoples R China
[3] Qingdao Mental Hlth Ctr, Dept Psychiat, Qingdao 266000, Peoples R China
[4] Tianjin Med Univ, Tianjin Anding Hosp, Mental Hlth Ctr, Dept Psychiat, 13 Liulin Rd, Tianjin 300222, Peoples R China
[5] Tianjin Med Univ, Tianjin Anding Hosp, Inst Mental Hlth, Mental Hlth Ctr, 13 Liulin Rd, Tianjin 300222, Peoples R China
关键词
Schizophrenia; Tardive dyskinesia; Catechol-O-methyltransferase; Psychiatric symptoms; Cognition; VAL158MET POLYMORPHISM; GENE; EXPRESSION; PATHOPHYSIOLOGY; SUSCEPTIBILITY; PREVALENCE; MECHANISMS; GENOTYPES;
D O I
10.1016/j.brainres.2023.148740
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Introduction: Catechol-O-methyltransferase (COMT) is a crucial enzyme involved in dopamine metabolism and has been implicated in the etiology of tardive dyskinesia (TD). We aimed to investigate the associations between COMT gene polymorphisms and the occurrence and severity of TD in a Chinese population, as well as the impact on the psychiatric symptoms and cognitive impairments observed in TD patients. Methods: A total of 216 chronic schizophrenia patients, including 59 TD patients and 157 NTD patients, were recruited for this study. Three SNPs of the COMT gene (rs4680, rs165599 and rs4818) were selected and genotyped using matrix -assisted laser desorption ionization time -of -flight mass spectrometry (MALDI-TOF-MS). TD severity, psychopathology and cognitive functioning were assessed using the Abnormal Involuntary Movement Scale (AIMS), the Positive and Negative Syndrome Scale (PANSS) and the Repeated Battery for Assessment of Neuropsychological Status (RBANS), respectively. Results: In TD patients, total AIMs scores were higher in carriers of the rs4680 AA genotype than in carriers of the AG and GG genotypes (p = 0.01, 0.006), carriers of the rs4818 GC and CC genotypes had higher orofacial scores than in GG genotypes (p = 0.032, 0.002). In male TD patients, carriers of the rs165599 GA genotype scored lower in the extremities and trunk scores than AA genotype carriers (p = 0.015). Moreover, in male TD patients, COMT rs4818 was associated with cognition, since the C allele carriers had significantly higher immediate memory (p = 0.043) and verbal function (p = 0.040) scores than the G allele carriers. In addition, rs165599 genotype interacted with TD diagnosis on depressed factor (p = 0.031). Conclusion: Within the Chinese population, COMT gene polymorphisms could potentially serve as biomarkers for the symptoms and prognosis of TD patients.
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页数:7
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