Chemical Synthesis of Substituted Naphthalene Derivatives: A Review

This review outlines progress in the synthesis of substitutednaphthalene derivatives. Naphthalene and its derivatives exhibit variousbiological activities such as anti-inflammatory, anticancer, antiviral, an-titubercular, antimicrobial, antihypertensive, antidiabetic, etc. Severalstrategies have been developed for the construction of naphthalene de-rivatives, primarily focused on metal-catalyzed reactions (palladium,copper, zinc, rhodium, platinum, nickel, etc.,) and Lewis acid catalyzedtransformations. This review discusses the preparations of naphthalenederivatives using various salts such as gallium chlorides, gold chlorides,gold bromides, various gold complexes as well as Br & oslash;nsted acids like tri-flic acid and trifluoroacetic acid, and Lewis acids such as boron trifluo-ride etherate. Additionally, miscellaneous types of reactions are ex-plored involving both metal and Lewis acids. The transformationalapproaches covered in this review include cycloadditions, carboannulations, benzannulations, electroannulations, rearrangements, and cross-dehydrogenative coupling reactions. Overall this review provides acomprehensive and up-to-date account of the current state of prepara-tions of substituted naphthalenes, highlighting their medicinal and in-dustrial importance