Nanodrug Delivery Strategies to Signaling Pathways in Alopecia

被引：5
作者：
Wu, Xiaochuan [1 ,2 ]
Du, Yong-zhong [1 ,2 ]
机构：
[1] Zhejiang Univ, Jinhua Inst, Jinhua 321299, Zhejiang, Peoples R China
[2] Zhejiang Univ, Inst Pharmaceut, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China
来源：
MOLECULAR PHARMACEUTICS | 2023年 / 20卷 / 11期
关键词：
hair regrowth; alopecia; signaling pathway; drug delivery; nanotechnology; DERMAL PAPILLA CELLS; MESENCHYMAL STEM-CELLS; PROMOTES HAIR-GROWTH; ANDROGENETIC ALOPECIA; LIPID NANOPARTICLES; IN-VITRO; WNT/BETA-CATENIN; CYCLOSPORINE-A; DOUBLE-BLIND; CROSS-TALK;
D O I：
10.1021/acs.molpharmaceut.3c00620
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Over 50% of the global population suffers from hair loss. The mixed results in the treatment of hair loss reveal the limitations of conventional commercial topical drugs. One the one hand, the definite pathogenesis of hair loss is still an enigma. On the other hand, targeted drug carriers ensure the drug therapeutic effect and low side effects. This review highlights the organization and overview of nine crucial signaling pathways associated with hair loss, as well as the development of nanobased topical delivery systems loading the clinical drugs, which will fuel emerging hair loss treatment strategies.
引用
收藏
页码：5396 / 5415
页数：20
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