CircRNA CircABCB1 Diminishes the Sensitivity of Breast Cancer Cells to Docetaxel by Sponging MiR-153-3p

被引：3

作者：

Liu, Jiaqi ^{[1
]}

Kong, Linna ^{[1
]}

Bian, Wenqing ^{[2
]}

Lin, Xiaona ^{[1
]}

Wei, Feifei ^{[3
]}

Chu, Jun ^{[1
,4
]}

机构：

[1] Zibo Cent Hosp, Dept Breast & Thyroid Surg, Zibo, Shandong, Peoples R China

[2] Maternal & Child Hlth Hosp Zibo, Zibo, Shandong, Peoples R China

[3] Weifang Maternal & Child Hlth Hosp, Weifang, Shandong, Peoples R China

[4] Zibo Cent Hosp, Dept Breast & Thyroid Surg, 54 Gongqingtuan West Rd, Zibo 255020, Shandong, Peoples R China

来源：

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 2023年 / 261卷 / 01期

关键词：

breast cancer; ceRNA; circABCB1; docetaxel resistance; prognosis; CIRCULAR RNA; RESISTANCE; CHEMOTHERAPY; PACLITAXEL; MECHANISMS;

D O I：

10.1620/tjem.2023.J039

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Resistance to docetaxel is a major problem to the success of docetaxel-based therapies for breast cancer. The present study was to identify the role of circABCB1 in altering the docetaxel resistance properties. Reverse transcription-quantitative PCR (qRT-PCR) was performed to quantify circABCB1 and miR-153-3p. The effects of circABCB1 on the viability, apoptosis and migration/invasion of docetaxel-resistant and-sensitive cells were investigated by cell function experiments, including Cell Counting Kit-8 and Transwell assays. Correlation between circABCB1 and the docetaxel-treated outcome was analyzed by multivariate Cox regression analysis, in addition to Kaplan-Meier analysis of time to treatment failure (TTF). The targeting relationship between circABCB1 and miR-153-3p was predicted and verified by dual-luciferase reporter assay and RNA immunoprecipitation. CircABCB1 was highly expressed in cancerous tissues, as well as the docetaxel-sensitive group and cells. The overexpression of circABCB1 contributed to cell viability, docetaxel-resistance and migration/invasion, but inhibited apoptosis. CircABCB1 can sponge miR-153-3p. CircABCB1 contributed to the docetaxel resistance of breast cancer, maybe via the miR-153-3p.

引用

页码：25 / 33

页数：9

共 33 条

[1] Awareness and current knowledge of breast cancer [J].

Akram, Muhammad ;

Iqbal, Mehwish ;

Daniyal, Muhammad ;

Khan, Asmat Ullah .

BIOLOGICAL RESEARCH, 2017, 50

[2] Circle RNA hsa_circRNA_100290 serves as a ceRNA for miR-378a to regulate oral squamous cell carcinoma cells growth via Glucose transporter-1 (GLUT1) and glycolysis [J].

Chen, Xing ;

Yu, Jianjun ;

Tian, Hao ;

Shan, Zhenfeng ;

Liu, Wei ;

Pan, Zhen ;

Ren, Jihao .

JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (11) :19130-19140

[3] De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017 [J].

Curigliano, G. ;

Burstein, H. J. ;

Winer, E. P. ;

Gnant, M. ;

Dubsky, P. ;

Loibl, S. ;

Colleoni, M. ;

Regan, M. M. ;

Piccart-Gebhart, M. ;

Senn, H. -J. ;

Thurlimann, B. ;

Andre, F. ;

Baselga, J. ;

Bergh, J. ;

Bonnefoi, H. ;

Brucker, S. Y. ;

Cardoso, F. ;

Carey, L. ;

Ciruelos, E. ;

Cuzick, J. ;

Denkert, C. ;

Di Leo, A. ;

Ejlertsen, B. ;

Francis, P. ;

Galimberti, V. ;

Garber, J. ;

Gulluoglu, B. ;

Goodwin, P. ;

Harbeck, N. ;

Hayes, D. F. ;

Huang, C. -S. ;

Huober, J. ;

Khaled, H. ;

Jassem, J. ;

Jiang, Z. ;

Karlsson, P. ;

Morrow, M. ;

Orecchia, R. ;

Osborne, K. C. ;

Pagani, O. ;

Partridge, A. H. ;

Pritchard, K. ;

Ro, J. ;

Rutgers, E. J. T. ;

Sedlmayer, F. ;

Semiglazov, V. ;

Shao, Z. ;

Smith, I. ;

Toi, M. ;

Tutt, A. .

ANNALS OF ONCOLOGY, 2017, 28 (08) :1700-1712

[4] New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1) [J].

Eisenhauer, E. A. ;

Therasse, P. ;

Bogaerts, J. ;

Schwartz, L. H. ;

Sargent, D. ;

Ford, R. ;

Dancey, J. ;

Arbuck, S. ;

Gwyther, S. ;

Mooney, M. ;

Rubinstein, L. ;

Shankar, L. ;

Dodd, L. ;

Kaplan, R. ;

Lacombe, D. ;

Verweij, J. .

EUROPEAN JOURNAL OF CANCER, 2009, 45 (02) :228-247

[5] Epigenetic mechanisms in breast cancer therapy and resistance [J].

Garcia-Martinez, Liliana ;

Zhang, Yusheng ;

Nakata, Yuichiro ;

Chan, Ho Lam ;

Morey, Lluis .

NATURE COMMUNICATIONS, 2021, 12 (01)

[6] The role of H19 lncRNA in conferring chemoresistance in cancer cells [J].

Ghafouri-Fard, Soudeh ;

Shoorei, Hamed ;

Bahroudi, Zahra ;

Abak, Atefe ;

Taheri, Mohammad .

BIOMEDICINE & PHARMACOTHERAPY, 2021, 138

[7] Silencing of circDPP4 suppresses cell progression of human prostate cancer and enhances docetaxel cytotoxicity through regulating the miR-564/ZIC2 axis [J].

Gu, Hao ;

Duan, Zhongqi .

JOURNAL OF GENE MEDICINE, 2022, 24 (03)

[8] Circular RNA and its mechanisms in disease: From the bench to the clinic [J].

Han, Bing ;

Chao, Jie ;

Yao, Honghong .

PHARMACOLOGY & THERAPEUTICS, 2018, 187 :31-44

[9] Circular RNA and miR-7 in Cancer [J].

Hansen, Thomas B. ;

Kjems, Jorgen ;

Damgaard, Christian K. .

CANCER RESEARCH, 2013, 73 (18) :5609-5612

[10] A Comprehensive RNA Study to Identify circRNA and miRNA Biomarkers for Docetaxel Resistance in Breast Cancer [J].

Huang, Peide ;

Li, Fengyu ;

Mo, Zongchao ;

Geng, Chunyu ;

Wen, Fang ;

Zhang, Chunyan ;

Guo, Jia ;

Wu, Song ;

Li, Lin ;

Brunner, Nils ;

Stenvang, Jan .

FRONTIERS IN ONCOLOGY, 2021, 11

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