Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease

被引：10

作者：

Bettinetti-Luque, Miriam ^{[1
]}

Trujillo-Estrada, Laura ^{[1
,2
]}

Garcia-Fuentes, Eduardo ^{[3
,4
]}

Andreo-Lopez, Juana ^{[1
]}

Sanchez-Varo, Raquel ^{[1
,2
,5
]}

Garrido-Sanchez, Lourdes ^{[6
,7
]}

Gomez-Mediavilla, Angela ^{[8
]}

Lopez, Manuela G. ^{[8
,9
]}

Garcia-Caballero, Melissa ^{[10
]}

Gutierrez, Antonia ^{[1
,2
]}

Baglietto-Vargas, David ^{[1
,2
,11
]}

机构：

[1] Univ Malaga, Fac Ciencias, Dept Biol Celular Genet & Fisiol, Inst Invest Biomed Malaga IBIMA Plataforma BIONAND, Malaga, Spain

[2] Inst Salud Carlos III, CIBER Enfermedades Neurodegenerat CIBERNED, Madrid, Spain

[3] Hosp Univ Virgen De La Victoria, Unidad Gest Clin Endocrinol & Nutr, Inst Invest Biomed Malaga IBIMA Plataforma BIONAND, Malaga, Spain

[4] Inst Salud Carlos III, CIBER Enfermedades Hepat & Digest CIBEREHD, Madrid, Spain

[5] Univ Malaga, Fac Med, Dept Fisiol Humana Anat Patol & Educ Fis Deport, Malaga, Spain

[6] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBEROBN, Madrid, Spain

[7] Hosp Univ Virgen De La Victoria, Unidad Gest Clin Endocrinol & Nutr, Inst Invest Biomed Malaga IBIMA Plataforma BIONAND, Malaga, Spain

[8] Univ Autonoma Madrid, Fac Med, Dept Farmacol, Inst Teofilo Hernando ID Farmacos, Madrid, Spain

[9] Hosp Univ La Princesa, Inst Invest Sanitarias Princesa IIS IP, Madrid, Spain

[10] Univ Malaga, Fac Ciencias, Dept Biol Mol & Bioquim, Inst Invest Biomed Malaga IBIMA Plataforma BIONAND, Malaga, Spain

[11] Univ Malaga, Fac Sci, Dept Cell Biol, Genet & Physiol, Malaga 29071, Spain

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2024年 / 181卷 / 06期

关键词：

adipokines; adipose tissue; Alzheimer's disease; amyloid; inflammation; tau; vascular; BLOOD-BRAIN-BARRIER; TUMOR-NECROSIS-FACTOR; INTERLEUKIN-1 RECEPTOR ANTAGONIST; TIGHT JUNCTION PROTEINS; AMYLOID PRECURSOR PROTEIN; TRANSGENIC MOUSE MODEL; BODY-MASS INDEX; NICOTINAMIDE MONONUCLEOTIDE PROTECTS; ENDOTHELIAL GROWTH-FACTOR; GLYCATION END-PRODUCTS;

D O I：

10.1111/bph.16243

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Adipose tissue has recently been recognized as an important endocrine organ that plays a crucial role in energy metabolism and in the immune response in many metabolic tissues. With this regard, emerging evidence indicates that an important crosstalk exists between the adipose tissue and the brain. However, the contribution of adipose tissue to the development of age-related diseases, including Alzheimer's disease, remains poorly defined. New studies suggest that the adipose tissue modulates brain function through a range of endogenous biologically active factors known as adipokines, which can cross the blood-brain barrier to reach the target areas in the brain or to regulate the function of the blood-brain barrier. In this review, we discuss the effects of several adipokines on the physiology of the blood-brain barrier, their contribution to the development of Alzheimer's disease and their therapeutic potential.

引用

页码：840 / 878

页数：39

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