Endothelial cell metabolism in sepsis

被引：16

作者：

Wei, Jue-xian ^{[1
]}

Jiang, Hui-lin ^{[1
]}

Chen, Xiao-hui ^{[1
]}

机构：

[1] Guangzhou Med Univ, Affiliated Hosp 2, Emergency Dept, Guangzhou 510260, Peoples R China

来源：

WORLD JOURNAL OF EMERGENCY MEDICINE | 2023年 / 14卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Sepsis; Endothelium; Metabolism; Glycolysis; Oxidative phosphorylation; Fatty acid metabolism; Amino acid metabolism; SYSTEMIC INFLAMMATION; DYSFUNCTION; EXPRESSION; ACID; INHIBITION; GLUCOSE-6-PHOSPHATE-DEHYDROGENASE; DEHYDROGENASE; ACTIVATION; GLYCOLYSIS; MIGRATION;

D O I：

10.5847/wjem.j.1920-8642.2023.019

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

BACKGROUND: Endothelial dysfunction in sepsis is a pathophysiological feature of septic organ failure. Endothelial cells (ECs) exhibit specific metabolic traits and release metabolites to adapt to the septic state in the blood to maintain vascular homeostasis. METHODS: Web of Science and PubMed were searched from inception to October 1, 2022. The search was limited to the English language only. Two reviewers independently identified studies related to EC metabolism in sepsis. The exclusion criteria were duplicate articles according to multiple search criteria. RESULTS: Sixty articles were included, and most of them were cell and animal studies. These studies reported the role of glycolysis, oxidative phosphorylation, fatty acid metabolism, and amino acid metabolism in EC homeostasis. including glycolysis, oxidative phosphorylation, fatty acid metabolism and amino acid metabolism. However, dysregulation of EC metabolism can contribute to sepsis progression. CONCLUSION: There are few clinical studies on EC metabolism in sepsis. Related research mainly focuses on basic research, but some scientific problems have also been clarified. Therefore, this review may provide an overall comprehension and novel aspects of EC metabolism in sepsis.

引用

页码：10 / 16

页数：7

共 62 条

[21] NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice [J].

Langbein, Heike ;

Brunssen, Coy ;

Hofmann, Anja ;

Cimalla, Peter ;

Brux, Melanie ;

Bornstein, Stefan R. ;

Deussen, Andreas ;

Koch, Edmund ;

Morawietz, Henning .

EUROPEAN HEART JOURNAL, 2016, 37 (22) :1753-1761

[22] N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1 [J].

Lawton, Samira K. ;

Xu, Fengyun ;

Tran, Alphonso ;

Wong, Erika ;

Prakash, Arun ;

Schumacher, Mark ;

Hellman, Judith ;

Wilhelmsen, Kevin .

JOURNAL OF IMMUNOLOGY, 2017, 199 (04) :1465-1475

[23] Red Blood Cell and Endothelial eNOS Independently Regulate Circulating Nitric Oxide Metabolites and Blood Pressure [J].

Leo, Francesca ;

Suvorava, Tatsiana ;

Heuser, Sophia K. ;

Li, Junjie ;

LoBue, Anthea ;

Barbarino, Frederik ;

Piragine, Eugenia ;

Schneckmann, Rebekka ;

Hutzler, Beate ;

Good, Miranda E. ;

Fernandez, Bernadette O. ;

Vornholz, Lukas ;

Rogers, Stephen ;

Doctor, Allan ;

Grandoch, Maria ;

Stegbauer, Johannes ;

Weitzberg, Eddie ;

Feelisch, Martin ;

Lundberg, Jon O. ;

Isakson, Brant E. ;

Kelm, Malte ;

Cortese-Krott, Miriam M. .

CIRCULATION, 2021, 144 (11) :870-889

[24] Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells [J].

Li, Meng ;

van Esch, Betty C. A. M. ;

Wagenaar, Gerry T. M. ;

Garssen, Johan ;

Folkerts, Gert ;

Henricks, Paul A. J. .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2018, 831 :52-59

[25]

Li M, 2018, FRONT PHARMACOL, V9, DOI [10.3389/fphar.2018.00233, 10.3389/fpsyg.2018.02420]

[26] Application of LC-MS-based metabolomics method in differentiating septic survivors from non-survivors [J].

Liu, Zhicheng ;

Yin, Peiyuan ;

Amathieu, Roland ;

Savarin, Philippe ;

Xu, Guowang .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2016, 408 (27) :7641-7649

[27] Arginine vasopressin receptor 2 activation promotes microvascular permeability in sepsis [J].

Lopez, Ernesto ;

Fukuda, Satoshi ;

Modis, Katalin ;

Fujiwara, Osamu ;

Enkhtaivan, Baigal ;

Trujillo-Abarca, Raul ;

Ihara, Koji ;

Lima-Lopez, Francisco ;

Perez-Bello, Dannelys ;

Szabo, Csaba ;

Prough, Donald S. ;

Enkhbaatar, Perenlei .

PHARMACOLOGICAL RESEARCH, 2021, 163

[28] Mitochondrial respiration supports autophagy to provide stress resistance during quiescence [J].

Magalhaes-Novais, Silvia ;

Blecha, Jan ;

Naraine, Ravindra ;

Mikesova, Jana ;

Abaffy, Pavel ;

Pecinova, Alena ;

Milosevic, Mirko ;

Bohuslavova, Romana ;

Prochazka, Jan ;

Khan, Shawez ;

Novotna, Eliska ;

Sindelka, Radek ;

Machan, Radek ;

Dewerchin, Mieke ;

Vlcak, Erik ;

Kalucka, Joanna ;

Stemberkova Hubackova, Sona ;

Benda, Ales ;

Goveia, Jermaine ;

Mracek, Tomas ;

Barinka, Cyril ;

Carmeliet, Peter ;

Neuzil, Jiri ;

Rohlenova, Katerina ;

Rohlena, Jakub .

AUTOPHAGY, 2022, 18 (10) :2409-2426

[29] The Pyruvate Dehydrogenase Complex Mitigates LPS-Induced Endothelial Barrier Dysfunction by Metabolic Regulation [J].

Mao, Liangfeng ;

Sun, Maomao ;

Chen, Zhenfeng ;

Zeng, Zhenhua ;

Wu, Jie ;

Chen, Zhongqing ;

Zhang, Weijin ;

Huang, Qiaobing .

SHOCK, 2022, 57 (06) :308-317

[30] Metabolic systems analysis of LPS induced endothelial dysfunction applied to sepsis patient stratification [J].

McGarrity, Sarah ;

Anuforo, Osk ;

Halldorsson, Haraldur ;

Bergmann, Andreas ;

Halldorsson, Skarpheoinn ;

Palsson, Sirus ;

Henriksen, Hanne H. ;

Johansson, Par Ingemar ;

Rolfsson, Ottar .

SCIENTIFIC REPORTS, 2018, 8

← 1 2 3 4 5 6 7 →