Monoclonal Antibodies in Pregnancy and Breastfeeding in Patients with Multiple Sclerosis: A Review and an Updated Clinical Guide

被引：8

作者：

Gklinos, Panagiotis ^{[1
]}

Dobson, Ruth ^{[2
,3
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Aeginit Univ Hosp, Dept Neurol, Athens 11528, Greece

[2] QMUL, Wolfson Inst Populat Hlth, Prevent Neurol Unit, London EC1M 6BQ, England

[3] Royal London Hosp, Dept Neurol, Barts Hlth NHS Trust, London E1 1FR, England

来源：

PHARMACEUTICALS | 2023年 / 16卷 / 05期

关键词：

multiple sclerosis; monoclonal antibodies; pregnancy; breastfeeding; disease-modifying therapies; review; PLACEBO-CONTROLLED TRIAL; RELAPSE RATE; DECISION-MAKING; NATALIZUMAB; INCREASE; OCRELIZUMAB; UBLITUXIMAB; EFFICACY; OUTCOMES; THERAPY;

D O I：

10.3390/ph16050770

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The use of high-efficacy disease-modifying therapies (DMTs) early in the course of multiple sclerosis (MS) has been shown to improve clinical outcomes and is becoming an increasingly popular treatment strategy. As a result, monoclonal antibodies, including natalizumab, alemtuzumab, ocrelizumab, ofatumumab, and ublituximab, are frequently used for the treatment of MS in women of childbearing age. To date, only limited evidence is available on the use of these DMTs in pregnancy. We aim to provide an updated overview of the mechanisms of action, risks of exposure and treatment withdrawal, and pre-conception counseling and management during pregnancy and post-partum of monoclonal antibodies in women with MS. Discussing treatment options and family planning with women of childbearing age is essential before commencing a DMT in order to make the most suitable choice for each individual patient.

引用

页数：13

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