Characterization of Anti-Poliovirus Compounds Isolated from Edible Plants

被引：2

作者：

Arita, Minetaro ^{[1
]}

Fuchino, Hiroyuki ^{[2
]}

机构：

[1] Natl Inst Infect Dis, Dept Virol 2, 4-7-1 Gakuen, Musashimurayama, Tokyo 2080011, Japan

[2] Natl Inst Biomed Innovat Hlth & Nutr, Res Ctr Med Plant Resources, 1-2 Hachimandai, Tsukuba, Ibaraki 3050843, Japan

来源：

VIRUSES-BASEL | 2023年 / 15卷 / 04期

基金：

日本学术振兴会;

关键词：

virus; picornavirus; enterovirus; antiviral; edible plant; PI4KB; OXYSTEROL-BINDING-PROTEIN; VITRO ANTIVIRAL ACTIVITY; 4-KINASE III-BETA; BROAD-SPECTRUM; ENTEROVIRUS REPLICATION; HUMAN RHINOVIRUS; INHIBITION; DRUG; RESVERATROL; RESISTANCE;

D O I：

10.3390/v15040903

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Poliovirus (PV) is the causative agent of poliomyelitis and is a target of the global eradication programs of the World Health Organization (WHO). After eradication of type 2 and 3 wild-type PVs, vaccine-derived PV remains a substantial threat against the eradication as well as type 1 wild-type PV. Antivirals could serve as an effective means to suppress the outbreak; however, no anti-PV drugs have been approved at present. Here, we screened for effective anti-PV compounds in a library of edible plant extracts (a total of 6032 extracts). We found anti-PV activity in the extracts of seven different plant species. We isolated chrysophanol and vanicoside B (VCB) as the identities of the anti-PV activities of the extracts of Rheum rhaponticum and Fallopia sachalinensis, respectively. VCB targeted the host PI4KB/OSBP pathway for its anti-PV activity (EC50 = 9.2 mu M) with an inhibitory effect on in vitro PI4KB activity (IC50 = 5.0 mu M). This work offers new insights into the anti-PV activity in edible plants that may serve as potent antivirals for PV infection.

引用

页数：14

共 82 条

[1] Polygonumins A, a newly isolated compound from the stem of Polygonum minus Huds with potential medicinal activities [J].

Ahmad, Rafidah ;

Sahidin, I. ;

Taher, Muhammad ;

Low, ChenFei ;

Noor, Normah Mohd ;

Sillapachaiyaporn, Chanin ;

Chuchawankul, Siriporn ;

Sarachana, Tewarit ;

Tencomnao, Tewin ;

Iskandar, Faizah ;

Rajab, Nor Fadilah ;

Baharum, Syarul Nataqain .

SCIENTIFIC REPORTS, 2018, 8

[2] Phosphatidylinositol 4-Kinase III Beta Is Essential for Replication of Human Rhinovirus and Its Inhibition Causes a Lethal Phenotype In Vivo [J].

Alastruey-Izquierdo, A. ;

Mellado, E. ;

Pelaez, T. ;

Peman, J. ;

Zapico, S. ;

Alvarez, M. ;

Rodriguez-Tudela, J. L. ;

Cuenca-Estrella, M. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (07) :3358-3368

[3] Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307 [J].

Albulescu, Lucian ;

Bigay, Joelle ;

Biswas, Bishyajit ;

Weber-Boyvat, Marion ;

Dorobantu, Cristina M. ;

Delang, Leen ;

van der Schaar, Hilde M. ;

Jung, Young-Sik ;

Neyts, Johan ;

Olkkonen, Vesa M. ;

van Kuppeveld, Frank J. M. ;

Strating, Jeroen R. P. M. .

ANTIVIRAL RESEARCH, 2017, 140 :37-44

[4] Insidious reintroduction of wild poliovirus into Israel, 2013 [J].

Anis, E. ;

Kopel, E. ;

Singer, S. R. ;

Kaliner, E. ;

Moerman, L. ;

Moran-Gilad, J. ;

Sofer, D. ;

Manor, Y. ;

Shulman, L. M. ;

Mendelson, E. ;

Gdalevich, M. ;

Lev, B. ;

Gamzu, R. ;

Grotto, I. .

EUROSURVEILLANCE, 2013, 18 (38) :2-6

[5] Characterization of pharmacologically active compounds that inhibit poliovirus and enterovirus 71 infectivity [J].

Arita, Minetaro ;

Wakita, Takaji ;

Shimizu, Hiroyuki .

JOURNAL OF GENERAL VIROLOGY, 2008, 89 :2518-2530

[6] Quantitative analysis of poliomyelitis-like paralysis in mice induced by a poliovirus replicon [J].

Arita, Minetaro ;

Nagata, Noriyo ;

Sata, Tetsutaro ;

Miyamura, Tatsuo ;

Shimizu, Hiroyuki .

JOURNAL OF GENERAL VIROLOGY, 2006, 87 :3317-3327

[7] High-Order Epistasis and Functional Coupling of Infection Steps Drive Virus Evolution toward Independence from a Host Pathway [J].

Arita, Minetaro .

MICROBIOLOGY SPECTRUM, 2021, 9 (02)

[8] Characterization of a New Antienterovirus D68 Compound Purified from Avocado [J].

Arita, Minetaro ;

Fuchino, Hiroyuki ;

Kawakami, Hitomi ;

Ezaki, Masami ;

Kawahara, Nobuo .

ACS INFECTIOUS DISEASES, 2020, 6 (08) :2291-2300

[9] Poliovirus Evolution toward Independence from the Phosphatidylinositol-4 Kinase III β/Oxysterol-Binding Protein Family I Pathway [J].

Arita, Minetaro ;

Bigay, Joelle .

ACS INFECTIOUS DISEASES, 2019, 5 (06) :962-973

[10] Allosteric Regulation of Phosphatidylinositol 4-Kinase Ill Beta by an Antipicornavirus Compound MDL-860 [J].

Arita, Minetaro ;

Dobrikov, Georgi ;

Puerstinger, Gerhard ;

Galabov, Angel S. .

ACS INFECTIOUS DISEASES, 2017, 3 (08) :585-594

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