Multimodal treatment of localized high-grade soft tissue sarcomas of the extremities Summary and discussion of the current S3 guidelines on adult soft tissue sarcomas and the ESMO guidelines on soft tissue and visceral sarcomas

被引：0

作者：

Schopow, Nikolas ^{[1
]}

Hohenberger, Peter ^{[2
]}

Gockel, Ines ^{[3
]}

Osterhoff, Georg ^{[1
]}

机构：

[1] Univ klinikum Leipzig, Klinik & Poliklin Orthopadie Unfallchirurg & Plast, Liebigstr 20, D-04103 Leipzig, Germany

[2] Univ klinikum Mannheim, Chirurg Klin, Sekt Spezielle Chirurg Onkol & Thoraxchirurg, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany

[3] Univ klinikum Leipzig, Klin Viszeral Transplantat Thorax & Gefasschirurg, Liebigstr 20, D-04103 Leipzig, Germany

来源：

CHIRURGIE | 2023年 / 94卷 / 05期

关键词：

Sarcoma; Extremity tumor; Tumor orthopedics; Oncologic surgery; Guideline; ESMO; RADIATION-THERAPY; IMPROVED SURVIVAL; CHEMOTHERAPY; RADIOTHERAPY; METAANALYSIS; RECURRENCE; RESECTION; PHASE-3; MARGIN; TUMORS;

D O I：

10.1007/s00104-023-01872-3

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Soft tissue sarcomas are rare, heterogeneous tumors that are frequently in the extremities. Treatment includes surgical resection, combination chemotherapy and/or radiotherapy, as well as supplementary procedures such as isolated limb perfusion and regional deep hyperthermia. The prognosis depends on the tumor stage and the approximately 70 histological subtypes, with specific treatment approaches existing only for some subtypes. This review summarizes the recommendations of the German S3 guideline "Adult Soft Tissue Sarcomas" and the European Society for Medical Oncology (ESMO) guideline "Soft tissue and visceral sarcomas" regarding the diagnostic workup and therapy of soft tissue sarcomas of the extremities.

引用

页码：424 / 431

页数：8

共 37 条

[1] External Beam Radiation Therapy for Resectable Soft Tissue Sarcoma: A Systematic Review and Meta-Analysis [J].

Albertsmeier, Markus ;

Rauch, Alexandra ;

Roeder, Falk ;

Hasenhuetl, Sandro ;

Pratschke, Sebastian ;

Kirschneck, Michaela ;

Gronchi, Alessandro ;

Jebsen, Nina L. ;

Cassier, Philippe A. ;

Sargos, Paul ;

Belka, Claus ;

Lindner, Lars H. ;

Werner, Jens ;

Angele, Martin K. .

ANNALS OF SURGICAL ONCOLOGY, 2018, 25 (03) :754-767

[2] Impact of residual disease after “unplanned excision” of primary localized adult soft tissue sarcoma of the extremities: evaluation of 452 cases at a single Institution [J].

Bianchi G. ;

Sambri A. ;

Cammelli S. ;

Galuppi A. ;

Cortesi A. ;

Righi A. ;

Caldari E. ;

Ferrari S. ;

Donati D. .

MUSCULOSKELETAL SURGERY, 2017, 101 (3) :243-248

[3] Local recurrence of localized soft tissue sarcoma [J].

Biau, David J. ;

Ferguson, Peter C. ;

Chung, Peter ;

Griffin, Anthony M. ;

Catton, Charles N. ;

O'Sullivan, Brian ;

Wunder, Jay S. .

CANCER, 2012, 118 (23) :5867-5877

[4] Core needle biopsy versus incisional biopsy for differentiation of soft-tissue sarcomas: A systematic review and meta-analysis [J].

Birgin, Emrullah ;

Yang, Cui ;

Hetjens, Svetlana ;

Reissfelder, Christoph ;

Hohenberger, Peter ;

Rahbari, Nuh N. .

CANCER, 2020, 126 (09) :1917-1928

[5] Improved survival using specialized multidisciplinary board in sarcoma patients [J].

Blay, J-Y ;

Soibinet, P. ;

Penel, N. ;

Bompas, E. ;

Duffaud, F. ;

Stoeckle, E. ;

Mir, O. ;

Adam, J. ;

Chevreau, C. ;

Bonvalot, S. ;

Rios, M. ;

Kerbrat, P. ;

Cupissol, D. ;

Anract, P. ;

Gouin, F. ;

Kurtz, J-E ;

Lebbe, C. ;

Isambert, N. ;

Bertucci, F. ;

Toumonde, M. ;

Thyss, A. ;

Piperno-Neumann, S. ;

Dubray-Longeras, P. ;

Meeus, P. ;

Ducimetiere, F. ;

Giraud, A. ;

Coindre, J-M ;

Ray-Coquard, I. ;

Italiano, A. ;

Le Cesne, A. .

ANNALS OF ONCOLOGY, 2017, 28 (11) :2852-2859

[6] The effect of an unplanned excision of a soft-tissue sarcoma on prognosis [J].

Chandrasekar, C. R. ;

Wafa, H. ;

Grimer, R. J. ;

Carter, S. R. ;

Tillman, R. M. ;

Abudu, A. .

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2008, 90B (02) :203-208

[7] Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma [J].

Davis, AM ;

O'Sullivan, B ;

Turcotte, R ;

Bell, R ;

Catton, C ;

Chabot, P ;

Wunder, J ;

Hammond, A ;

Benk, V ;

Kandel, R ;

Goddard, K ;

Zee, B ;

Day, A ;

Tu, DS ;

Pater, J .

RADIOTHERAPY AND ONCOLOGY, 2005, 75 (01) :48-53

[8] Isolated limb perfusion with tumor necrosis factor and melphalan for limb salvage in 186 patients with locally advanced soft tissue extremity sarcomas - The cumulative multicenter European experience [J].

Eggermont, AMM ;

Koops, HS ;

Klausner, JM ;

Kroon, BBR ;

Schlag, PM ;

Lienard, D ;

vanGeel, AN ;

Hoekstra, HJ ;

Meller, I ;

Nieweg, OE ;

Kettelhack, C ;

BenAri, G ;

Pector, JC ;

Lejeune, FJ .

ANNALS OF SURGERY, 1996, 224 (06) :756-765

[9] The role of surgical margin quality in myxofibrosarcoma and undifferentiated pleomorphic sarcoma [J].

Fujiwara, Tomohiro ;

Sumathi, Vaiyapuri ;

Parry, Michael ;

Stevenson, Jonathan ;

Tsuda, Yusuke ;

Kaneuchi, Yoichi ;

Jeys, Lee .

EJSO, 2021, 47 (07) :1756-1762

[10] Low-grade soft-tissue sarcomas: What is an adequate margin for local disease control? [J].

Fujiwara, Tomohiro ;

Kaneuchi, Yoichi ;

Tsuda, Yusuke ;

Stevenson, Jonathan ;

Parry, Michael ;

Jeys, Lee .

SURGICAL ONCOLOGY-OXFORD, 2020, 35 :303-308

← 1 2 3 4 →