Elevated STIL predicts poor prognosis in patients with hepatocellular carcinoma

被引：1
|
作者：
Song, Huangqin [1 ,2 ,3 ,4 ]
Zhao, Haichao [1 ,2 ,3 ,4 ]
Chen, Changzhou [3 ,4 ]
Zhang, Donglin [1 ,2 ,3 ,4 ]
Wang, Xiaoxiao [1 ,2 ,3 ,4 ]
He, Jiefeng [1 ,2 ,3 ,4 ,5 ,6 ]
机构：
[1] Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Hosp 3, Taiyuan, Peoples R China
[2] Fudan Univ, Zhongshan Hosp, Liver Canc Inst, Dept Liver Surg & Transplantat, Shanghai, Peoples R China
[3] Fudan Univ, Key Lab Carcinogenesis & Canc Invas, Minist Educ, Shanghai, Peoples R China
[4] Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China
[5] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan, Peoples R China
[6] Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Hosp 3, Taiyuan 030032, Peoples R China
来源：
MEDICINE | 2023年 / 102卷 / 07期
关键词：
hepatocellular carcinoma; immune infiltrates analyses; STIL; T-CELLS; CANCER;
D O I：
10.1097/MD.0000000000033004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Overexpression of SCL/TAL1 interrupting locus (STIL) has been observed in various cancer types. However, the clinical significance of STIL in hepatocellular carcinoma (HCC) remains unknown. Cox regression and Kaplan-Meier survival analyses were performed to evaluate the prognostic value of STIL. Go and Kyoto encyclopedia of genes and genomes (KEGG) enrichment analyses were also carried out. Immune infiltrates analyses were conducted based on TIMER (Tumor Immune Estimation Resource) and GAPIA databases. STIL expression was highly expressed in HCC tissues, based on multiple databases. KEGG and GO enrichment analysis showed STIL-related to tumorigenesis and progress. Furthermore, STIL was significantly correlated with immune infiltration. STIL serves as a biomarker for the prediction of patient survival.
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页数：8
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