Roles of cannabinoid CB1 and CB2 receptors in the modulation of psychostimulant responses

被引：4
作者：
Gobira, P. H. [1 ]
Joca, S. R. [1 ,2 ]
Moreira, F. A. [3 ]
机构：
[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Biomol Sci, Ribeirao Preto, SP, Brazil
[2] Aarhus Univ, Dept Biomed, Aarhus, Denmark
[3] Univ Fed Minas Gerais, Inst Biol Sci, Dept Pharmacol, Belo Horizonte, MG, Brazil
来源：
ACTA NEUROPSYCHIATRICA | 2024年 / 36卷 / 02期
基金：
巴西圣保罗研究基金会;
关键词：
psychostimulants; addiction; CB1; receptors; CB2; endocannabinoids; CONDITIONED PLACE PREFERENCE; NUCLEUS-ACCUMBENS DOPAMINE; CUE-INDUCED REINSTATEMENT; DRUG-ADDICTION; BEHAVIORAL SENSITIZATION; METHAMPHETAMINE-SEEKING; ENDOCANNABINOID SYSTEM; MONOAMINE TRANSPORTERS; MESOLIMBIC DOPAMINE; COCAINE SEEKING;
D O I：
10.1017/neu.2022.23
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Addiction to psychostimulant drugs, such as cocaine, D-amphetamine, and methamphetamine, is a public health issue that substantially contributes to the global burden of disease. Psychostimulant drugs promote an increase in dopamine levels within the mesocorticolimbic system, which is central to the rewarding properties of such drugs. Cannabinoid receptors (CB1R and CB2R) are expressed in the main areas of this system and implicated in the neuronal mechanisms underlying the rewarding effect of psychostimulant drugs. Here, we reviewed studies focusing on pharmacological intervention targeting cannabinoid CB1R and CB2R and their interaction in the modulation of psychostimulant responses.
引用
收藏
页码：67 / 77
页数：11
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