Changes of the Concentration of Short-Chain Fatty Acids in the Intestines of Mice with Different Types of Obesity

被引：6
作者：
Krolenko, E. V. [3 ]
Kupriyanova, O. V. [4 ]
Nigmatullina, L. S. [4 ]
Grigoryeva, T. V. [4 ]
Roumiantsev, S. A. [1 ,3 ,5 ]
Shestopalov, A. V. [1 ,2 ,3 ,5 ]
机构：
[1] LLC Ctr Mol Hlth, Ctr Digital & Translat Biomed, Moscow, Russia
[2] Minist Hlth Russian Federat, Dmitry Rogachev Natl Med Res Ctr Pediat Hematol On, Moscow, Russia
[3] Pirogov Russian Natl Res Med Univ, Minist Hlth Russian Federat, Moscow, Russia
[4] Kazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, Kazan, Republic Of Tat, Russia
[5] Minist Hlth Russian Federat, Natl Med Res Ctr Endocrinol, State Res Ctr, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2024年 / 176卷 / 03期
关键词：
alimentary obesity; genetic obesity; short-chain fatty acids; leptin resistance; PROTEIN-COUPLED RECEPTORS; SECRETION; PROPIONATE; PHYSIOLOGY;
D O I：
10.1007/s10517-024-06022-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the production of short-chain fatty acids (SCFA) by the intestinal microbiota in mice with obesity caused by a diet and a genetic defect in the leptin receptor gene. In mice, intestinal contents were examined and SCFA were quantitatively assayed by gas chromatography. SCFA concentration in the intestinal contents of mice with alimentary obesity model was significantly lower in the first phase of the experiment (day 14), and the change in their production in dynamics was fundamentally different from this process in the control group (standard diet). The dynamics of the concentration of these metabolites in the model of genetic obesity was similar to that in the control, but the production of SCFA was significantly reduced in mice with leptin resistance in the middle phase (day 60) of the experiment. These findings indicate that the production of SCFA is more influenced by the diet than by leptin resistance.
引用
收藏
页码：315 / 320
页数：6
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