Aging in Down syndrome: Neurocognitive and clinical profile

Down syndrome is a dominant neurodevelopmental disorder with a characteristic cognitive and clinical phenotype. Aging follows a special course and the phenomenon of accelerated aging is prevalent. Individuals, i.e., at the age of 25, begin to show cognitive declines, while their neurophysiological development is corresponding. This study attempts a complex approach to the key elements that contribute to the accelerated aging of this population. A synthesis of current research findings in the fields of otolaryngology, cardiology, gastroenterology, endocrinology, hematology, neurocognition and neurology is carried out and conclusions, useful for practical applications, are drawn.