Prospective study design and data analysis in UK Biobank

被引：27

作者：

Allen, Naomi E. ^{[1
,2
]}

Lacey, Ben ^{[1
,2
]}

Lawlor, Deborah A. ^{[3
,4
]}

Pell, Jill P. ^{[5
]}

Gallacher, John ^{[6
,7
]}

Smeeth, Liam ^{[8
]}

Elliott, Paul ^{[9
,10
]}

Matthews, Paul M. ^{[11
,12
]}

Lyons, Ronan A. ^{[13
]}

Whetton, Anthony D. ^{[14
]}

Lucassen, Anneke ^{[15
,16
]}

Hurles, Matthew E. ^{[17
]}

Chapman, Michael ^{[18
]}

Roddam, Andrew W. ^{[19
]}

Fitzpatrick, Natalie K. ^{[20
]}

Hansell, Anna L. ^{[21
]}

Hardy, Rebecca ^{[22
]}

Marioni, Riccardo E. ^{[23
]}

O'Donnell, Valerie B. ^{[24
]}

Williams, Julie ^{[25
]}

Lindgren, Cecilia M. ^{[26
]}

Effingham, Mark ^{[1
]}

Sellors, Jonathan ^{[1
]}

Danesh, John ^{[27
,28
,29
,30
,31
]}

Collins, Rory ^{[1
,2
]}

机构：

[1] UK Biobank Ltd, Stockport, England

[2] Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England

[3] Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, England

[4] Univ Bristol, Med Res Council Integrat Epidemiol Unit, Bristol, England

[5] Univ Glasgow, Sch Hlth & Wellbeing, Glasgow, Scotland

[6] Univ Oxford, Dept Psychiat, Oxford, England

[7] Univ Oxford, Dept Psychiat, Dementias Platform UK, Oxford, England

[8] London Sch Hyg & Trop Med, London, England

[9] Imperial Coll London, MRC Ctr Environm & Hlth, Sch Publ Hlth, London, England

[10] Imperial Coll London, NIHR Hlth Protect Res Unit Chem Radiat Threats & H, London, England

[11] Imperial Coll London, UK Dementia Res Ctr Inst, London, England

[12] Imperial Coll London, Dept Brain Sci, London, England

[13] Swansea Univ, Med Sch, Populat Data Sci, Swansea, Wales

[14] Univ Surrey, Vet Hlth Innovat Engine, Guildford, England

[15] Univ Oxford, Nuffield Dept Med, Oxford, England

[16] Southampton Univ, Fac Med, Southampton, England

[17] Wellcome Trust Sanger Inst, Wellcome Genome Campus, Cambridge, England

[18] NHS England, London, England

[19] Our Future Hlth, London, England

[20] UCL, Inst Hlth Informat, London, England

[21] Univ Leicester, Ctr Environm Hlth & Sustainabil, Leicester, England

[22] Loughborough Univ, Sch Sport Exercise & Hlth Sci, Loughborough, England

[23] Univ Edinburgh, Ctr Genom & Expt Med, Edinburgh, Scotland

[24] Cardiff Univ, Sch Med, Cardiff, Wales

[25] Cardiff Univ, UK Dementia Res Inst, Cardiff, Wales

[26] Univ Oxford, Big Data Inst, Li Ka Shing Ctr Hlth Informat & Discovery, Oxford, England

[27] Univ Cambridge, British Heart Fdn Cardiovasc Epidemiol Unit, Dept Publ Hlth & Primary Care, Cambridge, England

[28] Wellcome Genome Campus, Hlth Data Res UK Cambridge, Cambridge, England

[29] Univ Cambridge, Cambridge, England

[30] Univ Cambridge, Natl Inst Hlth Res Cambridge Biomed Res Ctr, Cambridge, England

[31] Cambridge Univ Hosp, Cambridge, England

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2024年 / 16卷 / 729期

关键词：

CORONARY-HEART-DISEASE; BODY-MASS INDEX; BLOOD-PRESSURE; COLLABORATIVE REANALYSIS; REGRESSION DILUTION; VASCULAR MORTALITY; INDIVIDUAL DATA; BREAST-CANCER; EPIC PROJECT; RISK-FACTORS;

D O I：

10.1126/scitranslmed.adf4428

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Population-based prospective studies, such as UK Biobank, are valuable for generating and testing hypotheses about the potential causes of human disease. We describe how UK Biobank's study design, data access policies, and approaches to statistical analysis can help to minimize error and improve the interpretability of research findings, with implications for other population-based prospective studies being established worldwide.

引用

页数：12

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