Association between psychological vulnerability and glaucoma progression: Protocol for a multicenter prospective cohort study in South Korea

被引:1
|
作者
Baek, Sung Uk [1 ,2 ]
Kim, Jin-Soo [3 ]
Kim, Dai Woo [4 ]
Ha, Ahnul [5 ,6 ]
Kim, Young Kook [7 ,8 ,9 ]
机构
[1] Hallym Univ, Coll Med, Dept Ophthalmol, Anyang, South Korea
[2] Hallym Univ, Dept Ophthalmol, Sacred Heart Hosp, Anyang, South Korea
[3] Chungnam Natl Univ, Dept Ophthalmol, Sejong Hosp, Sejong, South Korea
[4] Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Daegu, South Korea
[5] Jeju Natl Univ Hosp, Dept Ophthalmol, Jeju Si, South Korea
[6] Jeju Natl Univ, Sch Med, Dept Ophthalmol, Jeju Si, South Korea
[7] Seoul Natl Univ Hosp, Dept Ophthalmol, Seoul, South Korea
[8] Seoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
[9] EyeLight Data Sci Lab, Seoul, South Korea
来源
PLOS ONE | 2023年 / 18卷 / 10期
关键词
QUALITY-OF-LIFE; GENERALIZED ANXIETY DISORDER; VISUAL-FIELD PROGRESSION; INTRAOCULAR-PRESSURE; MEDICATION ADHERENCE; DEPRESSIVE SYMPTOMS; VALIDITY; PHQ-9; GAD-7;
D O I
10.1371/journal.pone.0292599
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
IntroductionMental health is a significant concern for patients diagnosed with glaucoma, as visual impairment can have a profound impact on psychological well-being. Conversely, psychological vulnerability in glaucoma patients can negatively influence treatment adherence to ocular hypotensive therapy, thereby potentially exacerbating disease progression in a vicious cycle. The study protocol proposed herein aims to explore the impact of psychological states such as anxiety, depression, and stress on both medication adherence and progression of glaucoma.Materials and methodsThis study is to be a prospective multicenter study conducted at four tertiary medical centers. Patients recently diagnosed with glaucoma and not yet treated will be enrolled. Anxiety, depression, and stress scales will be administered at baseline, one year, and two years, along with glaucomatous assessments to be performed every six months. Validated questionnaires (Generalized Anxiety Disorder Assessment [GAD-7], Patient Health Questionnaire [PHQ-9], and Perceived Stress Scale-10 [PSS-10]) will assess anxiety, depression, and stress, respectively. The primary objective is to correlate post-diagnosis psychological status with medication adherence and disease progression. The effects of pre- and post-diagnosis changes in anxiety, depression, and stress on disease progression will be analyzed. Kaplan-Meier survival analysis and logistic regression will be performed to identify clinical characteristics associated with increased risk of developing anxiety, depression, and stress in glaucoma patients.
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页数:11
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