FDG-Avid But Pentixafor-Negative in EBV-Associated T-Cell Lymphoproliferative Disorders

被引：3
作者：
Shu, Qiaoqiao [1 ,2 ,3 ]
He, Xubing [1 ,2 ,3 ]
Chen, Yue [1 ,2 ,3 ]
Cai, Liang [1 ,2 ,3 ]
机构：
[1] Southwest Med Univ, Dept Nucl Med, Affiliated Hosp, 25 TaiPing St, Luzhou 646000, Sichuan, Peoples R China
[2] Nucl Med & Mol Imaging Key Lab Sichuan Prov, Luzhou, Sichuan, Peoples R China
[3] Southwest Med Univ, Inst Nucl Med, Luzhou, Sichuan, Peoples R China
来源：
CLINICAL NUCLEAR MEDICINE | 2023年 / 48卷 / 08期
关键词：
hemophagocytic lymphohistiocytosis; lymphoproliferative disorders; F-18-FDG; Ga-68-pentixafor; PET/CT; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS;
D O I：
10.1097/RLU.0000000000004747
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
An 18-year-old woman with intermittent fever, pancytopenia, abnormal liver function, and enlarged lymph nodes and hepatosplenomegaly was clinically suspected as hemophagocytic lymphohistiocytosis. F-18-FDG PET/CT showed increased metabolism in multiple lymph nodes, which were highly suggestive of lymphoma. No increased CXCR4 expression in lymph nodes was demonstrated on Ga-68-pentixafor PET/CT. Subsequent right neck lymph node biopsy pathology revealed EBV-associated lymphoproliferative disorders. Our case shows that Ga-68-pentixafor PET/CT may have potential value in differentiating EBV-associated lymphoproliferative disorders from lymphomas.
引用
收藏
页码：714 / 715
页数：2
相关论文
共 10 条
[1]   Hemophagocytic lymphohistiocytosis in adults [J].
Bhatt, Neel S. ;
Oshrine, Benjamin ;
An Talano, Julie .
LEUKEMIA & LYMPHOMA, 2019, 60 (01) :19-28
[2]   Imaging of C-X-C Motif Chemokine Receptor 4 Expression in 690 Patients with Solid or Hematologic Neoplasms Using 68Ga-Pentixafor PET [J].
Buck, Andreas K. ;
Haug, Alexander ;
Dreher, Niklas ;
Lambertini, Alessandro ;
Higuchi, Takahiro ;
Lapa, Constantin ;
Weich, Alexander ;
Pomper, Martin G. ;
Wester, Hans-Juergen ;
Zehndner, Anja ;
Schirbel, Andreas ;
Samnick, Samuel ;
Hacker, Marcus ;
Pichler, Verena ;
Hahner, Stefanie ;
Fassnacht, Martin ;
Einsele, Hermann ;
Serfling, Sebastian E. ;
Werner, Rudolf A. .
JOURNAL OF NUCLEAR MEDICINE, 2022, 63 (11) :1687-1692
[3]   Histiocytic Disorders: Recent Insights into Pathophysiology and Practical Guidelines [J].
Filipovich, Alexandra ;
McClain, Kenneth ;
Grom, Alexei .
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2010, 16 (01) :S82-S89
[4]   EBV-Associated T-Cell Lymphoproliferative Disorders Demonstrated on FDG PET/CT in a Patient With Hemophagocytic Lymphohistiocytosis [J].
Hao, Ruirui ;
Yang, Xu ;
Liu, Zhimou ;
Yang, Jigang .
CLINICAL NUCLEAR MEDICINE, 2019, 44 (10) :829-830
[5]   Targeted positron emission tomography imaging of CXCR4 expression in patients with acute myeloid leukemia [J].
Herhaus, Peter ;
Habringer, Stefan ;
Philipp-Abbrederis, Kathrin ;
Vag, Tibor ;
Gerngross, Carlos ;
Schottelius, Margret ;
Slotta-Huspenina, Julia ;
Steiger, Katja ;
Altmann, Torben ;
Weisser, Tanja ;
Steidle, Sabine ;
Schick, Markus ;
Jacobs, Laura ;
Slawska, Jolanta ;
Mueller-Thomas, Catharina ;
Verbeek, Mareike ;
Subklewe, Marion ;
Peschel, Christian ;
Wester, Hans-Juergen ;
Schwaiger, Markus ;
Goetze, Katharina ;
Keller, Ulrich .
HAEMATOLOGICA, 2016, 101 (08) :932-940
[6]   Hemophagocytic lymphohistiocytosis in adults: Diagnosis and treatment [J].
Larroche, Claire .
JOINT BONE SPINE, 2012, 79 (04) :356-361
[7]   Investigation of spleen CXCR4 expression by [68Ga]Pentixafor PET in a cohort of 145 solid cancer patients [J].
Lewis, Richard ;
Habringer, Stefan ;
Kircher, Malte ;
Hefter, Maike ;
Peuker, Caroline Anna ;
Werner, Rudolf ;
Ademaj-Kospiri, Valeza ;
Gable, Alexander ;
Weber, Wolfgang ;
Wester, Hans-Jurgen ;
Buck, Andreas ;
Herhaus, Peter ;
Lapa, Constantin ;
Keller, Ulrich .
EJNMMI RESEARCH, 2021, 11 (01)
[8]   Diagnostic Challenges of Hemophagocytic Lymphohistiocytosis [J].
Otrock, Zaher K. ;
Daver, Naval ;
Kantarjian, Hagop M. ;
Eby, Charles S. .
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2017, 17 :S105-S110
[9]   Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis Mimicking Lymphoma on FDG PET/CT [J].
Pan, Qingqing ;
Luo, Yaping ;
Wu, Huanwen ;
Ma, Yanru ;
Li, Fang .
CLINICAL NUCLEAR MEDICINE, 2018, 43 (02) :125-127
[10]   The biology of chemokines and their receptors [J].
Rossi, D ;
Zlotnik, A .
ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :217-243
1