New heavy-atom-free bis(BODIPY)-based photosensitizer and its Pluronic® F127 water-soluble forms

被引：6

作者：

Antina, Lubov A. ^{[1
]}

Kalinkina, Valeria A. ^{[1
,2
]}

Sherudillo, Artem S. ^{[1
]}

Kalyagin, Alexander A. ^{[1
]}

Lukanov, Michail M. ^{[1
]}

Ksenofontov, Alexander A. ^{[1
]}

Berezin, Mikhail B. ^{[1
]}

Antina, Elena V. ^{[1
]}

机构：

[1] Russian Acad Sci, GA Krestov Inst Solut Chem, 1 Akad Skaya Str, Ivanovo 153045, Russia

[2] Ivanovo State Univ Chem & Technol, 7 Sheremetievskiy Ave, Ivanovo 153000, Russia

来源：

JOURNAL OF LUMINESCENCE | 2024年 / 269卷

基金：

俄罗斯科学基金会;

关键词：

CH(R)-bis(BODIPY) dimers; Photoinduced spin-orbital charge transfer enhanced ISC (SOCT-ISC); Pluronic (R) F127; Polymer micelles; Aggregation; EXCITED TRIPLET-STATE; PHOTODYNAMIC THERAPY; BODIPY-DIMERS; NUCLEOPHILIC-SUBSTITUTION; CANCER; NANOPARTICLES; DERIVATIVES; GENERATION;

D O I：

10.1016/j.jlumin.2023.120411

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Photosensitizers (PS) with optimal photophysical characteristics are necessary for an integrated approach to the diagnosis and treatment of diseases various types using photodynamic therapy (PDT). This study explores the potential of CH(R)-bis(BODIPY) dyes 1-4, 3a, and 3b as heavy-atom-free photosensitizers. A detailed computer study of CH(R)-bis(BODIPY) dyes demonstrates the role of SOCT-ISC (photoinduced spin-orbital charge transfer enhanced ISC) in the 4,4-CH2-bis(BODIPY) 4 photosensitizing properties implementation. The design strategies of a novel water-soluble polymer nanophotosensitizes 4-NPs, based on a dimeric dye 4 and a biocompatible amphiphilic block copolymer Pluronic (R) F127 are presented. A comparative analysis of dye 4 solubilization efficiency and its spectral properties in the composition of supramolecular 4-NP systems obtained by different techniques, as well as the sizes of the resulting nanostructures, was carried out.

引用

页数：12

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